KEGG   ENZYME: 2.1.1.296Help
Entry
EC 2.1.1.296                Enzyme                                 

Name
methyltransferase cap2;
MTR2;
cap2-MTase;
mRNA (nucleoside-2'-O)-methyltransferase (ambiguous)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-ribonucleotide-[mRNA] 2'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA] [RN:R10812]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA] [CPD:C04802]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA] [CPD:C20862]
Comment
The enzyme, found in higher eukaryotes including insects and vertebrates, and their viruses, methylates the ribose of the ribonucleotide at the second transcribed position of mRNAs and snRNAs. This methylation event is known as cap2. The human enzyme can also methylate mRNA molecules where the upstream purine ribonucleotide is not methylated (see EC 2.1.1.57, methyltransferase cap1), but with lower efficiency [2].
History
EC 2.1.1.296 created 2014
Orthology
K14590  
cap2 methyltransferase
K18776  
cap2 methyltransferase
Genes
HSA: 
55783(CMTR2)
PTR: 
745202(CMTR2)
PPS: 
100985401(CMTR2)
GGO: 
101137210(FTSJD1)
PON: 
100172540(CMTR2)
NLE: 
100579817(CMTR2)
MCC: 
711529(CMTR2)
MCF: 
102120594(CMTR2)
CSAB: 
103233165(CMTR2)
RRO: 
104677811(CMTR2)
CJC: 
100412690(CMTR2)
SBQ: 
101045320(CMTR2)
MMU: 
234728(Cmtr2)
RNO: 
292016(Cmtr2)
CGE: 
100754099(Cmtr2)
NGI: 
103735630(Cmtr2)
HGL: 
101696697(Cmtr2)
OCU: 
100346528(CMTR2)
TUP: 
102482679(CMTR2)
CFA: 
489718(CMTR2)
AML: 
100482851(CMTR2)
UMR: 
103673582(CMTR2)
FCA: 
101081592(CMTR2)
PTG: 
102969106(CMTR2)
BTA: 
781914(CMTR2)
BOM: 
102269376(CMTR2)
PHD: 
102332669(CMTR2)
CHX: 
102182998(CMTR2)
OAS: 
101106100(CMTR2)
SSC: 
100625187(CMTR2)
CFR: 
102518757(CMTR2)
BACU: 
103017175(CMTR2)
LVE: 
103086480(CMTR2)
ECB: 
100068485(CMTR2)
MYB: 
102252269(CMTR2)
MYD: 
102758049(CMTR2)
PALE: 
102893817(CMTR2)
LAV: 
100671400(CMTR2)
MDO: 
100024780(CMTR2)
SHR: 
100914522(CMTR2)
OAA: 
100074514(CMTR2)
GGA: 
427537(CMTR2)
MGP: 
100550810(CMTR2)
CJO: 
107319188(CMTR2)
APLA: 
101802442(CMTR2)
TGU: 
100230404(CMTR2)
GFR: 
102044295(CMTR2)
FAB: 
101817347(CMTR2)
PHI: 
102112750(CMTR2)
CCW: 
104687521(CMTR2)
FPG: 
101913175(CMTR2)
FCH: 
102045864(CMTR2)
CLV: 
102092901(CMTR2)
AAM: 
106489389(CMTR2)
ASN: 
102379025(CMTR2)
AMJ: 
102567886(CMTR2)
PSS: 
102462904(CMTR2)
CMY: 
102941834(CMTR2)
ACS: 
100566866(cmtr2)
PBI: 
103049103(CMTR2)
GJA: 
107109618(CMTR2)
XTR: 
100496665(cmtr2)
DRE: 
406742(cmtr2)
TRU: 
101076967(cmtr2)
TNG: 
MZE: 
101481599(cmtr2)
OLA: 
101158006(cmtr2)
XMA: 
102226934(cmtr2)
SASA: 
106562241(cmtr2)
LCM: 
102351997(CMTR2)
CMK: 
103172567(cmtr2)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD11317(Dsim_GD11317)
DWI: 
DYA: 
Dyak_GE11900(dyak_GLEANR_12192)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
TCA: 
BMOR: 
DPL: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CELE_Y40D12A.1(Y40D12A.1)
CBR: 
BMY: 
LOA: 
HRO: 
LGI: 
CRG: 
OBI: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
CRE: 
VCN: 
MBR: 
SRE: 
TAN: 
TPV: 
TOT: 
BEQ: 
BBO: 
BBOV_I003250(19.m02092)
CPV: 
TGO: 
PTM: 
GTT: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:16516986]
  Authors
Arhin GK, Ullu E, Tschudi C
  Title
2'-O-methylation of position 2 of the trypanosome spliced leader cap 4 is mediated by a 48 kDa protein related to vaccinia virus VP39.
  Journal
Mol. Biochem. Parasitol. 147 (2006) 137-9.
  Sequence
Reference
2  [PMID:21310715]
  Authors
Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM
  Title
2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family.
  Journal
Nucleic. Acids. Res. 39 (2011) 4756-68.
  Sequence
[hsa:55783]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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