KEGG   ENZYME: 2.1.1.299Help
Entry
EC 2.1.1.299                Enzyme                                 

Name
protein N-terminal monomethyltransferase;
NRMT2 (gene name);
METTL11B (gene name);
N-terminal monomethylase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-[protein] monomethyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein]
Substrate
S-adenosyl-L-methionine [CPD:C00019];
N-terminal-(A,P,S)PK-[protein]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N-terminal-N-methyl-N-(A,P,S)PK-[protein]
Comment
This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal.
History
EC 2.1.1.299 created 2014
Orthology
K19579  
protein N-terminal monomethyltransferase
Genes
HSA: 
149281(METTL11B)
PTR: 
469577(METTL11B)
PPS: 
100987718(METTL11B)
GGO: 
101152939(METTL11B)
PON: 
100444887(METTL11B)
NLE: 
100586787(METTL11B)
MCC: 
705503(METTL11B)
MCF: 
102119511(METTL11B)
CSAB: 
103230610(METTL11B)
RRO: 
104669430(METTL11B)
CJC: 
100411855(METTL11B)
SBQ: 
101045661(METTL11B)
MMU: 
240879(Mettl11b)
RNO: 
289167(Mettl11b)
CGE: 
100752444(Mettl11b)
NGI: 
103727098(Mettl11b)
HGL: 
OCU: 
100346292(METTL11B)
TUP: 
102475213(METTL11B)
CFA: 
490351(METTL11B)
AML: 
100466656(METTL11B)
UMR: 
103667791(METTL11B)
FCA: 
101084764(METTL11B)
PTG: 
102967658(METTL11B)
BTA: 
521303(METTL11B)
BOM: 
102274395(METTL11B)
PHD: 
102320091(METTL11B)
CHX: 
102172563(METTL11B)
OAS: 
101103252(METTL11B)
SSC: 
100157210(METTL11B)
CFR: 
102523187(METTL11B)
BACU: 
103016571(METTL11B)
LVE: 
103073590(METTL11B)
ECB: 
100059169(METTL11B)
MYB: 
102255085(METTL11B)
MYD: 
102754821(METTL11B)
PALE: 
102885906(METTL11B)
LAV: 
100661734(METTL11B)
MDO: 
100019985(METTL11B)
SHR: 
100922386(METTL11B)
OAA: 
100084060(METTL11B)
GGA: 
429066(METTL11B)
MGP: 
104909323(METTL11B)
CJO: 
107317298(METTL11B)
APLA: 
101799335(METTL11B)
TGU: 
100223826(METTL11B)
GFR: 
102040508(METTL11B)
FAB: 
101821734(METTL11B)
PHI: 
102112950(METTL11B)
CCW: 
104695457(METTL11B)
FPG: 
101921234(METTL11B)
FCH: 
102057343(METTL11B)
CLV: 
102084074(METTL11B)
AAM: 
106493883(METTL11B)
ASN: 
102370453(METTL11B)
AMJ: 
102575018(METTL11B)
PSS: 
102446567(METTL11B)
CMY: 
102935596(METTL11B)
ACS: 
100555292(mettl11b)
PBI: 
103057111(METTL11B)
GJA: 
107106117(METTL11B)
XTR: 
100485318(mettl11b)
DRE: 
568419(mettl11b)
TRU: 
101074892(mettl11b)
TNG: 
MZE: 
101485145(mettl11b)
OLA: 
101166618(mettl11b)
XMA: 
102226777(mettl11b)
SASA: 
LCM: 
102347657(METTL11B)
CMK: 
103179979(mettl11b)
 » show all
Taxonomy
Reference
1  [PMID:24090352]
  Authors
Petkowski JJ, Bonsignore LA, Tooley JG, Wilkey DW, Merchant ML, Macara IG, Schaner Tooley CE
  Title
NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1.
  Journal
Biochem. J. 456 (2013) 453-62.
  Sequence
[hsa:149281]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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