KEGG   ENZYME: 2.1.1.301Help
Entry
EC 2.1.1.301                Enzyme                                 

Name
cypemycin N-terminal methyltransferase;
CypM
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:N-terminal L-alanine-[cypemycin] N-methyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + N-terminal L-alanine-[cypemycin] = 2 S-adenosyl-L-homocysteine + N-terminal N,N-dimethyl-L-alanine-[cypemycin]
Substrate
S-adenosyl-L-methionine [CPD:C00019];
N-terminal L-alanine-[cypemycin]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N-terminal N,N-dimethyl-L-alanine-[cypemycin]
Comment
The enzyme, isolated from the bacterium Streptomyces sp. OH-4156, can methylate a variety of linear oligopeptides, cyclic peptides such as nisin and haloduracin, and the epsilon-amino group of lysine [2]. Cypemycin is a peptide antibiotic, a member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides.
History
EC 2.1.1.301 created 2014
Reference
1  [PMID:20805503]
  Authors
Claesen J, Bibb M
  Title
Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 107 (2010) 16297-302.
  Sequence
Reference
2  [PMID:22841713]
  Authors
Zhang Q, van der Donk WA
  Title
Catalytic promiscuity of a bacterial alpha-N-methyltransferase.
  Journal
FEBS. Lett. 586 (2012) 3391-7.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system