KEGG   ENZYME: 2.1.1.302Help
Entry
EC 2.1.1.302                Enzyme                                 

Name
3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase;
AziB2
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3-hydroxy-5-methyl-1-naphthoate = S-adenosyl-L-homocysteine + 3-methoxy-5-methyl-1-naphthoate [RN:R10962]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3-hydroxy-5-methyl-1-naphthoate [CPD:C20805]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
3-methoxy-5-methyl-1-naphthoate [CPD:C20980]
Comment
The enzyme from the bacterium Streptomyces sahachiroi is involved in the biosynthesis of 3-methoxy-5-methyl-1-naphthoate, a component of of the the antitumor antibiotic azinomycin B.
History
EC 2.1.1.302 created 2014
Reference
1  [PMID:20485749]
  Authors
Ding W, Deng W, Tang M, Zhang Q, Tang G, Bi Y, Liu W
  Title
Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the  antitumor antibiotic azinomycin B.
  Journal
Mol. Biosyst. 6 (2010) 1071-81.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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