KEGG   ENZYME: 2.1.1.304Help
Entry
EC 2.1.1.304                Enzyme                                 

Name
L-tyrosine C3-methyltransferase;
SfmM2;
SacF
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:L-tyrosine C3-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + L-tyrosine = S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine [RN:R10964]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
L-tyrosine [CPD:C00082]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
3-methyl-L-tyrosine [CPD:C20800]
Comment
The enzyme from the bacterium Streptomyces lavendulae is involved in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family.
History
EC 2.1.1.304 created 2014
Reference
1  [PMID:22187429]
  Authors
Tang MC, Fu CY, Tang GL
  Title
Characterization of SfmD as a Heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis.
  Journal
J. Biol. Chem. 287 (2012) 5112-21.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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