KEGG   ENZYME: 2.1.1.305Help
Entry
EC 2.1.1.305                Enzyme                                 

Name
8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase;
ElmMI
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C = S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [RN:R10956]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
8-demethyl-8-alpha-L-rhamnosyltetracenomycin C [CPD:C20974]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [CPD:C20975]
Comment
The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin.
History
EC 2.1.1.305 created 2014
Pathway
Biosynthesis of type II polyketide products
Biosynthesis of antibiotics
Orthology
K19567  
8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
Reference
1  [PMID:11376004]
  Authors
Patallo EP, Blanco G, Fischer C, Brana AF, Rohr J, Mendez C, Salas JA.
  Title
Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes.
  Journal
J. Biol. Chem. 276 (2001) 18765-74.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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