KEGG   ENZYME: 2.1.1.38Help
Entry
EC 2.1.1.38                 Enzyme                                 

Name
O-demethylpuromycin O-methyltransferase;
O-demethylpuromycin methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin [RN:R03633]
Reaction(KEGG)
R03633;
(other) R05676
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Substrate
S-adenosyl-L-methionine [CPD:C00019];
O-demethylpuromycin [CPD:C02864]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
puromycin [CPD:C01610]
Comment
Puromycin is the antibiotic derived from N6-dimethyladenosine by replacing the 3'-hydroxy group with an amino group and acylating this with 4-O-methyltyrosine.
History
EC 2.1.1.38 created 1972
Pathway
Puromycin biosynthesis
Biosynthesis of secondary metabolites
Orthology
K12635  
O-demethylpuromycin-O-methyltransferase
Reference
1  [PMID:5773275]
  Authors
Rao MM, Rebello PF, Pogell BM.
  Title
Biosynthesis of puromycin in Streptomyces alboniger. Enzymatic methylation of O-demethylpuromycin.
  Journal
J. Biol. Chem. 244 (1969) 112-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37257-04-8

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