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Entry
EC 2.1.1.4                  Enzyme                                 

Name
acetylserotonin O-methyltransferase;
hydroxyindole methyltransferase;
hydroxyindole O-methyltransferase;
N-acetylserotonin O-methyltransferase;
acetylserotonin methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin [RN:R03130]
Reaction(KEGG)
R03130;
(other) R04905
Show
Substrate
S-adenosyl-L-methionine [CPD:C00019];
N-acetylserotonin [CPD:C00978]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
melatonin [CPD:C01598]
Comment
Some other hydroxyindoles also act as acceptor, but more slowly.
History
EC 2.1.1.4 created 1961
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K00543  acetylserotonin O-methyltransferase
K22588  acetylserotonin O-methyltransferase, plant
Genes
HSA: 438(ASMT)
PTR: 107971195(ASMT)
PPS: 100968232(ASMT)
GGO: 101151339(ASMT)
PON: 100457801(ASMT)
NLE: 100594711
MCC: 574350(ASMT)
MCF: 102128713
CSAB: 103232876(ASMT)
RBB: 108516657(ASMT)
CJC: 100406578(ASMT)
MMU: 107626(Asmt)
RNO: 246281(Asmt)
NGI: 103750116(Asmt)
HGL: 101697837(Asmt)
TUP: 102472243(ASMT)
CFA: 100683688(ASMT)
AML: 100466738(ASMT)
UMR: 103666293(ASMT)
ORO: 101380092(ASMT)
FCA: 101101365(ASMT)
PTG: 102965330(ASMT)
AJU: 106982046(ASMT)
BTA: 281013(ASMT)
BOM: 102278615(ASMT)
PHD: 102333278(ASMT)
CHX: 100861249(ASMT)
OAS: 101114754(ASMT)
SSC: 110258194
CFR: 102511012(ASMT) 102512015
CDK: 105103096(ASMT)
BACU: 103008325(ASMT)
LVE: 103086659(ASMT)
OOR: 101269606(ASMT)
ECB: 100146729(ASMT)
EPZ: 103544951(ASMT)
EAI: 106821899(ASMT)
MYB: 102248110(ASMT)
MYD: 102766854(ASMT)
HAI: 109375564(ASMT)
RSS: 109438146(ASMT)
PALE: 102895851(ASMT)
LAV: 100656176(ASMT)
TMU: 101351625
MDO: 100010602(ASMT)
SHR: 100931838(ASMT)
GGA: 396286(ASMT)
MGP: 100547251(ASMT)
CJO: 107305906(ASMT)
APLA: 101796277(ASMT)
ACYG: 106035745(ASMT)
TGU: 100223806(ASMT)
GFR: 102034059(ASMT)
FAB: 101816146(ASMT)
PHI: 102106159(ASMT)
PMAJ: 107211015(ASMT)
CCW: 104686012(ASMT)
FPG: 101921940(ASMT)
FCH: 102059795(ASMT)
CLV: 102093193(ASMT)
EGZ: 104125159(ASMT)
AAM: 106490940(ASMT)
ASN: 102386765(ASMT)
AMJ: 102575782(ASMT)
PSS: 102457160(ASMT) 102457574
PBI: 103059937(ASMT)
GJA: 107120387(ASMT)
XLA: 108707446(asmt.L) 108709071(asmt.S)
XTR: 496888(asmt)
NPR: 108793182(ASMT)
DRE: 100141344(asmt)
AMEX: 103034755 103044675(asmt)
TRU: 101072678(asmt) 101079954
LCO: 104923845(asmt) 104937665
NCC: 104942862(asmt)
MZE: 101473716 101482331(asmt)
OLA: 101155734 101166758(asmt)
XMA: 102225007(asmt) 102236297
PRET: 103461453(asmt)
CSEM: 103392244(asmt)
LCF: 108892755(asmt) 108902203
HCQ: 109521119 109531283(asmt)
ELS: 105015875 105016360(asmt)
SFM: 108920780 108929286(asmt)
LCM: 102347098(ASMT)
CMK: 103177093(asmt)
SKO: 100376491
ATH: AT4G35160
CSAT: 104729695
BRP: 103834365
BNA: 106421710
BOE: 106329225
FVE: 101308058
PPER: 109948539
PMUM: 103343486
PAVI: 110770388
MDM: 103427860
PXB: 103936842
DOSA: Os09t0344500-01(Os09g0344500)
BDI: 100827387
ATS: 109738391(LOC109738391)
 » show all
Taxonomy
Reference
1  [PMID:13685335]
  Authors
AXELROD J, WEISSBACH H.
  Title
Purification and properties of hydroxyindole-O-methyl transferase.
  Journal
J. Biol. Chem. 236 (1961) 211-3.
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.4
IUBMB Enzyme Nomenclature: 2.1.1.4
ExPASy - ENZYME nomenclature database: 2.1.1.4
BRENDA, the Enzyme Database: 2.1.1.4
CAS: 9029-77-0

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