KEGG   ENZYME: 2.1.1.4Help
Entry
EC 2.1.1.4                  Enzyme                                 

Name
acetylserotonin O-methyltransferase;
hydroxyindole methyltransferase;
hydroxyindole O-methyltransferase;
N-acetylserotonin O-methyltransferase;
acetylserotonin methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin [RN:R03130]
Reaction(KEGG)
R03130;
(other) R04905
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Substrate
S-adenosyl-L-methionine [CPD:C00019];
N-acetylserotonin [CPD:C00978]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
melatonin [CPD:C01598]
Comment
Some other hydroxyindoles also act as acceptor, but more slowly.
History
EC 2.1.1.4 created 1961
Pathway
Tryptophan metabolism
Metabolic pathways
Orthology
K00543  
acetylserotonin N-methyltransferase
Genes
HSA: 
438(ASMT)
PPS: 
100968232(ASMT)
GGO: 
101151339(ASMT)
PON: 
MCC: 
574350(ASMT)
MCF: 
MMU: 
107626(Asmt)
RNO: 
246281(Asmt)
HGL: 
101697837(Asmt)
TUP: 
102472243(ASMT)
CFA: 
100683688(ASMT)
AML: 
FCA: 
101101365(ASMT)
BTA: 
281013(ASMT)
BOM: 
102278615(ASMT)
PHD: 
102333278(ASMT)
CHX: 
100861249(HIOMT)
CFR: 
ECB: 
100146729(ASMT)
MYB: 
102248110(ASMT)
MDO: 
SHR: 
100931838(ASMT)
OAA: 
GGA: 
396286(ASMT)
MGP: 
TGU: 
100223806(ASMT)
FAB: 
101816146(ASMT)
PHI: 
102106159(ASMT)
APLA: 
101796277(ASMT)
FPG: 
101921940(ASMT)
FCH: 
102059795(ASMT)
CLV: 
102093193(ASMT)
ASN: 
102386765(ASMT)
PSS: 
ACS: 
XTR: 
496888(asmt)
DRE: 
100141344(asmt)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102347098(ASMT)
SMW: 
PPRC: 
CVI: 
BMA: 
BMV: 
BML: 
BMN: 
BPS: 
BPM: 
BPL: 
BPD: 
BPR: 
BPSE: 
BPZ: 
BPQ: 
BPK: 
 » show all
Taxonomy
Reference
1  [PMID:13685335]
  Authors
AXELROD J, WEISSBACH H.
  Title
Purification and properties of hydroxyindole-O-methyl transferase.
  Journal
J. Biol. Chem. 236 (1961) 211-3.
  Organism
Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-77-0

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