KEGG   ENZYME: 2.1.1.44Help
Entry
EC 2.1.1.44                 Enzyme                                 

Name
L-histidine Nalpha-methyltransferase;
dimethylhistidine N-methyltransferase;
dimethylhistidine methyltransferase;
histidine-alpha-N-methyltransferase;
S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase;
S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine Nalpha-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase (hercynine-forming)
Reaction(IUBMB)
3 S-adenosyl-L-methionine + L-histidine = 3 S-adenosyl-L-homocysteine + hercynine (overall reaction) [RN:R01169];
(1a) S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + Nalpha-methyl-L-histidine [RN:R10523];
(1b) S-adenosyl-L-methionine + Nalpha-methyl-L-histidine = S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine [RN:R10524];
(1c) S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + hercynine [RN:R04436]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
L-histidine [CPD:C00135];
Nalpha-methyl-L-histidine;
Nalpha,Nalpha-dimethyl-L-histidine [CPD:C04259]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
hercynine [CPD:C05575];
Nalpha-methyl-L-histidine;
Nalpha,Nalpha-dimethyl-L-histidine [CPD:C04259]
Comment
Part of the biosynthetic pathway of ergothioneine.
Reference
1  [PMID:5484456]
  Authors
Ishikawa Y, Melville DB.
  Title
The enzymatic alpha-N-methylation of histidine.
  Journal
J. Biol. Chem. 245 (1970) 5967-73.
  Organism
Neurospora crassa [GN:ncr]
Reference
2  [PMID:20420449]
  Authors
Seebeck FP
  Title
In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.
  Journal
J. Am. Chem. Soc. 132 (2010) 6632-3.
  Organism
Mycobacterium smegmatis [GN:msg]
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
62213-53-0

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