KEGG   ENZYME: 2.1.1.44Help
Entry
EC 2.1.1.44                 Enzyme                                 

Name
L-histidine Nalpha-methyltransferase;
dimethylhistidine N-methyltransferase;
dimethylhistidine methyltransferase;
histidine-alpha-N-methyltransferase;
S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase;
S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine Nalpha-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase (hercynine-forming)
Reaction(IUBMB)
3 S-adenosyl-L-methionine + L-histidine = 3 S-adenosyl-L-homocysteine + hercynine (overall reaction) [RN:R01169];
(1a) S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + Nalpha-methyl-L-histidine [RN:R10523];
(1b) S-adenosyl-L-methionine + Nalpha-methyl-L-histidine = S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine [RN:R10524];
(1c) S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + hercynine [RN:R04436]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
L-histidine [CPD:C00135];
Nalpha-methyl-L-histidine;
Nalpha,Nalpha-dimethyl-L-histidine [CPD:C04259]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
hercynine [CPD:C05575];
Nalpha-methyl-L-histidine;
Nalpha,Nalpha-dimethyl-L-histidine [CPD:C04259]
Comment
Part of the biosynthetic pathway of ergothioneine.
History
EC 2.1.1.44 created 1976, modified 2013
Pathway
ec00340  Histidine metabolism
Orthology
K18911  L-histidine Nalpha-methyltransferase
K20246  L-histidine Nalpha-methyltransferase / hercynylcysteine S-oxide synthase
Genes
SMO: SELMODRAFT_440291 SELMODRAFT_441187
MNG: MNEG_11096
APRO: F751_0470
NCR: NCU04343(egt-1)
NTE: NEUTE1DRAFT145472(NEUTE1DRAFT_145472)
SMP: SMAC_01803
PAN: PODANSg6176 PODANSg6177
TTT: THITE_2115901
MTM: MYCTH_2074210
CTHR: CTHT_0030600
MBE: MBM_01989
ANI: AN7620.2
ANG: ANI_1_792134(An15g05880)
PNO: SNOG_13930(SNOG_13929)
PTE: PTT_06791
SPO: SPBC1604.01(mug158)
CNE: CNJ01670
CNB: CNBJ1790
ABP: AGABI1DRAFT112491(AGABI1DRAFT_112491) AGABI1DRAFT120644(AGABI1DRAFT_120644)
ABV: AGABI2DRAFT186400(AGABI2DRAFT_186400) AGABI2DRAFT192459(AGABI2DRAFT_192459)
TGR: Tgr7_2473
TKM: TK90_0941
TVR: TVD_07835
MXA: MXAN_7473
MTU: Rv3701c(egtD)
MTC: MT3804
MRA: MRA_3737
MTUR: CFBS_3922
MTD: UDA_3701c
MTUE: J114_19770
MTUL: TBHG_03636
MTUT: HKBT1_3906
MTUU: HKBT2_3916
MBB: BCG_3760c
MBT: JTY_3762
MBX: BCGT_3563
MAF: MAF_37090
MMIC: RN08_4081
MPA: MAP_0303c
MAO: MAP4_3568
MAVI: RC58_17730
MAVU: RE97_17760
MAV: MAV_0402
MAVD: NF84_01845
MAVR: LA63_01905
MAVA: LA64_01915
MIT: OCO_03550
MIA: OCU_03620
MID: MIP_00739
MYO: OEM_03670
MIR: OCQ_03570
MMAL: CKJ54_01715(egtD)
MVA: Mvan_5483
MGI: Mflv_1318
MPHL: MPHLCCUG_00354(egtD)
MVQ: MYVA_5373
MUL: MUL_4285
MAB: MAB_0372
MABB: MASS_0368
MABO: NF82_01865
MCHE: BB28_01815
MSTE: MSTE_00331(egtD)
MMC: Mmcs_4879
MKM: Mkms_4968
MJL: Mjls_5247
MMI: MMAR_5212
MMM: W7S_01745
MHAD: B586_03755
ASD: AS9A_2107
NFA: NFA_48840
NFR: ERS450000_05025(egtD)
NNO: NONO_c66340(egtD)
NSR: NS506_01661(egtD)
NTP: CRH09_33200(egtD) CRH09_34695(egtD)
RER: RER_43170
REY: O5Y_20230
ROP: ROP_57720
REQ: REQ_12490
RHB: NY08_2330
RFA: A3L23_00519(egtD)
RHS: A3Q41_02834(egtD)
RRZ: CS378_22375(egtD)
RHU: A3Q40_02531(egtD)
RQI: C1M55_21745(egtD)
SRT: Srot_1375
SCO: SCO0913(SCM1.46)
SMA: SAVERM_7338(egtD)
SGR: SGR_698
SGB: WQO_31700
SCT: SCAT_4662
SFA: Sfla_0407
SHY: SHJG_7892
SVE: SVEN_6867
SALB: XNR_5669
SALS: SLNWT_7175
STRP: F750_6592
SFI: SFUL_6743
SLV: SLIV_33365(egtD)
SGU: SGLAU_29355(egtD)
STRE: GZL_01890
SLD: T261_1097
STRM: M444_29575
SAMB: SAM23877_6627(egtD)
SPRI: SPRI_0731
SRW: TUE45_00191(egtD)
SLE: sle_06860(sle_06860)
SRN: A4G23_05242(egtD)
SNR: SNOUR_08415(egtD)
STRD: NI25_03155
SMAL: SMALA_7430
SLAU: SLA_6648
SLX: SLAV_06120(egtD)
KSK: KSE_64540
LMOI: VV02_12415
NCA: Noca_1639
NDK: I601_1452(egtD)
KFL: Kfla_5160
PSIM: KR76_00175
NDA: Ndas_0640
NAL: B005_3535
NGV: CDO52_21005(egtD)
TCU: Tcur_3638
SRO: Sros_0329
FAL: FRAAL6843
NML: Namu_1079
GOB: Gobs_0202
SEN: SACE_3823
AMD: AMED_4961
AMN: RAM_25255
AMM: AMES_4902
AMZ: B737_4902
AOI: AORI_3755
AJA: AJAP_20380(egtD)
AMYC: CU254_17960(egtD)
PSEE: FRP1_09630
PSEH: XF36_09105
AMI: Amir_2125
APRE: CNX65_10835(egtD)
SESP: BN6_30880
KAL: KALB_2953
ACTI: UA75_11540
ACAD: UA74_11455
AHG: AHOG_10790(egtD)
ACTA: C1701_22040(egtD)
SAQ: Sare_2259
MIL: ML5_4986
ASE: ACPL_6424
AFS: AFR_38625
PLK: CIK06_14635(egtD)
CAI: Caci_8031
SNA: Snas_5171
TBI: Tbis_2648
AEY: CDG81_09260(egtD)
RXY: Rxyl_0685
CWO: Cwoe_4694
GBA: J421_1882
MPY: Mpsy_2947
 » show all
Taxonomy
Reference
1  [PMID:5484456]
  Authors
Ishikawa Y, Melville DB.
  Title
The enzymatic alpha-N-methylation of histidine.
  Journal
J. Biol. Chem. 245 (1970) 5967-73.
Reference
2  [PMID:20420449]
  Authors
Seebeck FP
  Title
In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.
  Journal
J. Am. Chem. Soc. 132 (2010) 6632-3.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.44
IUBMB Enzyme Nomenclature: 2.1.1.44
ExPASy - ENZYME nomenclature database: 2.1.1.44
BRENDA, the Enzyme Database: 2.1.1.44
CAS: 62213-53-0

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