KEGG   ENZYME: 2.1.1.44Help
Entry
EC 2.1.1.44                 Enzyme                                 

Name
L-histidine Nalpha-methyltransferase;
dimethylhistidine N-methyltransferase;
dimethylhistidine methyltransferase;
histidine-alpha-N-methyltransferase;
S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase;
S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine Nalpha-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase (hercynine-forming)
Reaction(IUBMB)
3 S-adenosyl-L-methionine + L-histidine = 3 S-adenosyl-L-homocysteine + hercynine (overall reaction) [RN:R01169];
(1a) S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + Nalpha-methyl-L-histidine [RN:R10523];
(1b) S-adenosyl-L-methionine + Nalpha-methyl-L-histidine = S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine [RN:R10524];
(1c) S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + hercynine [RN:R04436]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
L-histidine [CPD:C00135];
Nalpha-methyl-L-histidine;
Nalpha,Nalpha-dimethyl-L-histidine [CPD:C04259]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
hercynine [CPD:C05575];
Nalpha-methyl-L-histidine;
Nalpha,Nalpha-dimethyl-L-histidine [CPD:C04259]
Comment
Part of the biosynthetic pathway of ergothioneine.
History
EC 2.1.1.44 created 1976, modified 2013
Pathway
Histidine metabolism
Orthology
K18911  
L-histidine Nalpha-methyltransferase
Genes
MXA: 
MFU: 
MSD: 
CCX: 
SUR: 
MTU: 
Rv3701c(egtD)
MTV: 
MTC: 
MRA: 
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTI: 
MTE: 
MTUR: 
MTL: 
MTO: 
MTD: 
MTN: 
MTJ: 
MTUB: 
MTUE: 
MTX: 
MTUL: 
MTUT: 
MTUU: 
MTQ: 
MBO: 
MBB: 
MBT: 
MBM: 
MBK: 
MBZ: 
MAF: 
MCE: 
MCQ: 
MCV: 
MCX: 
MCZ: 
MPA: 
MAO: 
MAV: 
MAVR: 
MAVD: 
MIT: 
MIR: 
MIA: 
MIE: 
MID: 
MYO: 
MSM: 
MSG: 
MSB: 
MSA: 
MSN: 
MSH: 
MUL: 
MVA: 
MGI: 
MSP: 
MAB: 
MABB: 
MMV: 
MAY: 
MABO: 
MAZ: 
MAK: 
MMC: 
MKM: 
MJL: 
MJD: 
MMI: 
MRH: 
MMM: 
MCB: 
MLI: 
MKN: 
MNE: 
ASD: 
NFA: 
NCY: 
NBR: 
NNO: 
RHA: 
RER: 
REY: 
ROP: 
ROA: 
REQ: 
RPY: 
SRT: 
SCO: 
SCO0913(SCM1.46)
SMA: 
SGR: 
SCB: 
SSX: 
SVL: 
SCT: 
SCY: 
SFA: 
SBH: 
SHY: 
SHO: 
SVE: 
SDV: 
SALB: 
STRP: 
SFI: 
SCI: 
SRC: 
SALU: 
SLV: 
SGU: 
KSK: 
NCA: 
KFL: 
NDA: 
NAL: 
TCU: 
SRO: 
FRA: 
FRE: 
FRI: 
FAL: 
FSY: 
NML: 
GOB: 
SEN: 
SVI: 
TBI: 
AMD: 
AMN: 
AMM: 
AMZ: 
AOI: 
AJA: 
AMQ: 
PDX: 
AMI: 
SESP: 
KAL: 
STP: 
SAQ: 
MAU: 
MIL: 
VMA: 
AMS: 
ASE: 
ACTN: 
AFS: 
CAI: 
SNA: 
RXY: 
CWO: 
 » show all
Taxonomy
Reference
1  [PMID:5484456]
  Authors
Ishikawa Y, Melville DB.
  Title
The enzymatic alpha-N-methylation of histidine.
  Journal
J. Biol. Chem. 245 (1970) 5967-73.
Reference
2  [PMID:20420449]
  Authors
Seebeck FP
  Title
In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.
  Journal
J. Am. Chem. Soc. 132 (2010) 6632-3.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
62213-53-0

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