KEGG   ENZYME: 2.1.1.46Help
Entry
EC 2.1.1.46                 Enzyme                                 

Name
isoflavone 4'-O-methyltransferase;
4'-hydroxyisoflavone methyltransferase;
isoflavone methyltransferase;
isoflavone O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:4'-hydroxyisoflavone 4'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a 4'-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 4'-methoxyisoflavone
Substrate
S-adenosyl-L-methionine [CPD:C00019];
4'-hydroxyisoflavone
Product
S-adenosyl-L-homocysteine [CPD:C00021];
4'-methoxyisoflavone
Comment
Requires Mg2+ for activity. The enzyme catalyses the methylation of daidzein and genistein. It does not methylate naringenin, apigenin, luteolin or kaempferol.
History
EC 2.1.1.46 created 1976, modified 2011
Orthology
K13259  
2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase / isoflavone 4'-O-methyltransferase
Genes
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
Taxonomy
Reference
1  [PMID:4452353]
  Authors
Wengenmayer H, Ebel J, Grisebach H.
  Title
Purification and properties of a S-adenosylmethionine: isoflavone 4'-O-methyltransferase from cell suspension cultures of Cicer arietinum L.
  Journal
Eur. J. Biochem. 50 (1974) 135-43.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
55071-80-2

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