KEGG   ENZYME: 2.1.1.47Help
Entry
EC 2.1.1.47                 Enzyme                                 

Name
indolepyruvate C-methyltransferase;
ind1 (gene name);
indolepyruvate methyltransferase;
indolepyruvate 3-methyltransferase;
indolepyruvic acid methyltransferase;
S-adenosyl-L-methionine:indolepyruvate C-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(indol-3-yl)pyruvate C3-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (R)-3-(indol-3-yl)-2-oxobutanoate [RN:R01972]
Reaction(KEGG)
R01972;
(other) R01973
Show
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(indol-3-yl)pyruvate [CPD:C00331]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(R)-3-(indol-3-yl)-2-oxobutanoate [CPD:C21289]
Comment
The enzyme, characterized from the bacterium Streptomyces griseus, is involved in the biosynthesis of the antibacterial drug indolmycin.
History
EC 2.1.1.47 created 1976, modified 2016
Pathway
Tryptophan metabolism
Reference
1  [PMID:5490210]
  Authors
Hornemann U, Speedie MK, Hurley LH, Floss HG.
  Title
Demonstration of a C-methylating enzyme in cell free extracts of indolmycin-producing Streptomyces griseus.
  Journal
Biochem. Biophys. Res. Commun. 39 (1970) 594-9.
Reference
2  [PMID:5095271]
  Authors
Hornemann U, Hurley LH, Speedie MK, Floss HG
  Title
The biosynthesis of indolmycin.
  Journal
J. Am. Chem. Soc. 93 (1971) 3028-35.
Reference
3  [PMID:809439]
  Authors
Speedie MK, Hornemann U, Floss HG
  Title
Isolation and characterization of tryptophan transaminase and indolepyruvate C-methyltransferase. Enzymes involved in indolmycin biosynthesis in Streptomyces  griseus.
  Journal
J. Biol. Chem. 250 (1975) 7819-25.
Reference
4  [PMID:25730866]
  Authors
Du YL, Alkhalaf LM, Ryan KS
  Title
In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 112 (2015) 2717-22.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
54576-88-4

DBGET integrated database retrieval system