KEGG   ENZYME: 2.1.1.59Help
Entry
EC 2.1.1.59                 Enzyme                                 

Name
[cytochrome c]-lysine N-methyltransferase;
cytochrome c (lysine) methyltransferase;
cytochrome c methyltransferase;
cytochrome c-specific protein methylase III;
cytochrome c-specific protein-lysine methyltransferase;
S-adenosyl-L-methionine:[cytochrome c]-L-lysine 6-N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[cytochrome c]-L-lysine N6-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + [cytochrome c]-L-lysine = S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine [RN:R04145]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[cytochrome c]-L-lysine
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[cytochrome c]-N6-methyl-L-lysine
Comment
One of a group of enzymes methylating proteins; see also EC 2.1.1.43 histone-lysine N-methyltransferase and EC 2.1.1.60 calmodulin-lysine N-methyltransferase.
History
EC 2.1.1.59 created 1982, modified 1983
Pathway
ec00310  Lysine degradation
Orthology
K18804  [cytochrome c]-lysine N-methyltransferase
Genes
SCE: YHR109W(CTM1)
AGO: AGOS_AER246W
KLA: KLLA0E21407g
KMX: KLMA_20447(CTM1)
LTH: KLTH0F16390g
VPO: Kpol_530p1
ZRO: ZYRO0F09680g
CGR: CAGL0I01210g
NCS: NCAS_0H02000(NCAS0H02000)
NDI: NDAI_0C01650(NDAI0C01650)
TPF: TPHA_0E01820(TPHA0E01820)
TDL: TDEL_0E02050(TDEL0E02050)
KAF: KAFR_0D04990(KAFR0D04990)
PIC: PICST_86656(CTM1)
CAL: CAALFM_CR10360CA(CTM1)
CAUR: QG37_03282
 » show all
Taxonomy
Reference
1  [PMID:203592]
  Authors
Durban E, Nochumson S, Kim S, Paik WK, Chan SK.
  Title
Cytochrome c-specific protein-lysine methyltransferase from Neurospora crassa. Purification, characterization, and substrate requirements.
  Journal
J. Biol. Chem. 253 (1978) 1427-35.
Reference
2  [PMID:196592]
  Authors
Nochumson S, Durban E, Kim S, Paik WK.
  Title
Cytochrome c-specific protein methylase III from Neurospora crassa.
  Journal
Biochem. J. 165 (1977) 11-8.
Reference
3  [PMID:6282265]
  Authors
Valentine J, Pettigrew GW.
  Title
A cytochrome c methyltransferase from Crithidia oncopelti.
  Journal
Biochem. J. 201 (1982) 329-38.
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.59
IUBMB Enzyme Nomenclature: 2.1.1.59
ExPASy - ENZYME nomenclature database: 2.1.1.59
BRENDA, the Enzyme Database: 2.1.1.59
CAS: 82047-78-7

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