8-hydroxyfuranocoumarin 8-O-methyltransferase;
furanocoumarin 8-methyltransferase;
furanocoumarin 8-O-methyl-transferase;
xanthotoxol 8-O-methyltransferase;
XMT;
8-hydroxyfuranocoumarin 8-O-methyltransferase;
SAM:xanthotoxol O-methyltransferase;
S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase;
xanthotoxol methyltransferase;
xanthotoxol O-methyltransferase;
S-adenosyl-L-methionine:xanthotoxol O-methyltransferase;
S-adenosyl-L-methionine-xanthotoxol O-methyltransferase

Transferases;
Transferring one-carbon groups;
Methyltransferases

S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase

(1) S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin = S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin (general reaction) [RN:R02982];
(2) S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin

R02982

S-adenosyl-L-methionine [CPD:C00019];
8-hydroxyfurocoumarin;
xanthotoxol [CPD:C00841]

Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities [4]. Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols (see also EC 2.1.1.69, 5-hydroxyfuranocoumarin 5-O-methyltransferase).

1  [PMID:28084]

Thompson HJ, Sharma SK, Brown SA.

O-methyltransferases of furanocoumarin biosynthesis.

Arch. Biochem. Biophys. 188 (1978) 272-81.

Ruta graveolens, Heracleum lanatum

2

Hauffe, K.D., Hahlbrock, K. and Scheel, D.

Elicitor-stimulated furanocoumarin biosynthesis in cultured parsley cells - S-adenosyl-L-methionine-bergaptol and S-adenosyl-L-methionine-xanthotoxol O-methyltransferases.

Z. Naturforsch. C: Biosci. 41 (1986) 228-239.

3  [PMID:156999]

Sharma SK, Garrett JM, Brown SA.

Separation of the S-adenosylmethionine: 5- and 8-hydroxyfuranocoumarin O-methyltransferases of Ruta graveolens L. by general ligand affinity chromatography.

Z. Naturforsch. [C]. 34C (1979) 387-91.

Ruta graveolens

4  [PMID:15009205]

Hehmann M, Lukacin R, Ekiert H, Matern U.

Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase.

Eur. J. Biochem. 271 (2004) 932-40.

Ammi majus