KEGG   ENZYME: 2.1.1.70Help
Entry
EC 2.1.1.70                 Enzyme                                 

Name
8-hydroxyfuranocoumarin 8-O-methyltransferase;
furanocoumarin 8-methyltransferase;
furanocoumarin 8-O-methyl-transferase;
xanthotoxol 8-O-methyltransferase;
XMT;
8-hydroxyfuranocoumarin 8-O-methyltransferase;
SAM:xanthotoxol O-methyltransferase;
S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase;
xanthotoxol methyltransferase;
xanthotoxol O-methyltransferase;
S-adenosyl-L-methionine:xanthotoxol O-methyltransferase;
S-adenosyl-L-methionine-xanthotoxol O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin = S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin (general reaction) [RN:R02982];
(2) S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
8-hydroxyfurocoumarin;
xanthotoxol [CPD:C00841]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
8-methoxyfurocoumarin;
xanthotoxin [CPD:C01864]
Comment
Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities [4]. Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols (see also EC 2.1.1.69, 5-hydroxyfuranocoumarin 5-O-methyltransferase).
History
EC 2.1.1.70 created 1984, modified 2006 (EC 2.1.1.93 created 2006, incorporated 2008)
Reference
1  [PMID:28084]
  Authors
Thompson HJ, Sharma SK, Brown SA.
  Title
O-methyltransferases of furanocoumarin biosynthesis.
  Journal
Arch. Biochem. Biophys. 188 (1978) 272-81.
Reference
2
  Authors
Hauffe, K.D., Hahlbrock, K. and Scheel, D.
  Title
Elicitor-stimulated furanocoumarin biosynthesis in cultured parsley cells - S-adenosyl-L-methionine-bergaptol and S-adenosyl-L-methionine-xanthotoxol O-methyltransferases.
  Journal
Z. Naturforsch. C: Biosci. 41 (1986) 228-239.
Reference
3  [PMID:156999]
  Authors
Sharma SK, Garrett JM, Brown SA.
  Title
Separation of the S-adenosylmethionine: 5- and 8-hydroxyfuranocoumarin O-methyltransferases of Ruta graveolens L. by general ligand affinity chromatography.
  Journal
Z. Naturforsch. [C]. 34C (1979) 387-91.
Reference
4  [PMID:15009205]
  Authors
Hehmann M, Lukacin R, Ekiert H, Matern U.
  Title
Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase.
  Journal
Eur. J. Biochem. 271 (2004) 932-40.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
67339-13-3

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