KEGG   ENZYME: 2.1.1.71Help
Entry
EC 2.1.1.71                 Enzyme                                 
Name
phosphatidyl-N-methylethanolamine N-methyltransferase;
phosphatidylmonomethylethanolamine methyltransferase;
methyltransferase II;
phospholipid methyltransferase;
PLMT;
phosphatidyl-N-methylethanolamine methyltransferase;
phosphatidyl-N-monomethylethanolamine methyltransferase;
phosphatidylethanolamine methyltransferase I;
phosphatidylmonomethylethanolamine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine [RN:R03424]
Reaction(KEGG)
R03424;
(other) R01320
Show
Substrate
S-adenosyl-L-methionine [CPD:C00019];
phosphatidyl-N-methylethanolamine [CPD:C01241]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
phosphatidyl-N-dimethylethanolamine [CPD:C04308]
Comment
The enzyme also catalyses the transfer of a further methyl group, producing phosphatidylcholine.
Pathway
Glycerophospholipid metabolism
Metabolic pathways
Orthology
K00570  
phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase
Genes
LPN: 
lpg2158(pmtA)
LPU: 
LPF: 
LPP: 
LPA: 
LPE: 
LLO: 
MCA: 
NOC: 
NHL: 
NWA: 
Nwat_0780
HHA: 
Hhal_0826
TKM: 
TK90_0730
TNI: 
TVNIR_0902 TVNIR_3104
EBA: 
ebA6680(pemT)
DAO: 
Desac_0447
MLO: 
mll4753
MCI: 
Mesci_0723
MOP: 
Mesop_0741
MAM: 
Mesau_00706
MES: 
Meso_0681
PLA: 
Plav_2189
SME: 
SMc00414
SMK: 
Sinme_3664
SMQ: 
SinmeB_3440
SMX: 
SM11_chr3811(pmtA)
SMI: 
BN406_03465
SMEG: 
C770_GR4Chr0342
SMEL: 
SM2011_c00414(pmtA)
SMD: 
Smed_3542
RHI: 
NGR_c36740
SFH: 
SFHH103_03905
SFD: 
USDA257_c61800
ATU: 
Atu0300
ARA: 
Arad_0541
AVI: 
Avi_0349
AGR: 
AGROH133_03436(pmtA)
RET: 
RHE_CH00316 RHE_CH01201
REC: 
RHECIAT_CH0000354(pmtA1) RHECIAT_CH0001293
RLE: 
RL0333(pmtA) RL1338(pmtA)
RLT: 
Rleg2_0843 Rleg2_4327
RLG: 
Rleg_0964 Rleg_4590
RTR: 
RTCIAT899_CH01960(pmtA)
LCC: 
B488_01150
BME: 
BMEI2000
BMI: 
BMEA_A2189
BMZ: 
BM28_A2116
BMG: 
BM590_A2117
BMW: 
BMNI_I2028
BMF: 
BAB1_2131
BMB: 
BruAb1_2102(pmtA)
BMC: 
BAbS19_I19930
BAA: 
BAA13334_I00574
BMS: 
BR2127(pmtA)
BSI: 
BS1330_I2121(pmtA)
BMT: 
BSUIS_A1967
BSV: 
BSVBI22_A2123(pmtA)
BOV: 
BOV_2043(pmtA)
BCS: 
BCAN_A2172
BSK: 
BCA52141_I1794
BMR: 
BMI_I2149(pmtA)
BPP: 
BPI_I2185(pmtA)
OAN: 
Oant_0788
BJA: 
bll6634(pmtA) bll6994 blr0681(pmtA)
BJU: 
BJ6T_06480 BJ6T_24110 BJ6T_27910
BRA: 
BRADO0162(pmtA) BRADO5696 BRADO5893
BBT: 
BBta_0193(pmtA) BBta_1882 BBta_6211
BRS: 
S23_01550(pmtA) S23_13110(pmtX1) S23_16750(pmtA)
RPA: 
RPA0335 RPA1307
RPB: 
RPB_0431 RPB_4115
RPC: 
RPC_0331 RPC_0988
RPD: 
RPD_0389 RPD_3961
RPE: 
RPE_0347 RPE_1038
RPT: 
Rpal_0338 Rpal_1497
RPX: 
Rpdx1_0292 Rpdx1_4145
NWI: 
Nwi_0199 Nwi_0604 Nwi_0696
NHA: 
Nham_0157 Nham_0696
OCA: 
OCAR_4419 OCAR_5206
OCG: 
OCA5_c01120 OCA5_c27610(pmtA2)
OCO: 
OCA4_c01120 OCA4_c27600(pmtA2)
AOL: 
S58_01770 S58_19180 S58_60710
XAU: 
Xaut_0355 Xaut_0403
AZC: 
AZC_0161 AZC_4349
SNO: 
Snov_2498 Snov_4025
MEX: 
Mext_2962 Mext_4097
MEA: 
Mex_1p3166(pmtA) Mex_1p4487
MDI: 
METDI3731(pmtA) METDI5092
MCH: 
Mchl_3188 Mchl_4465
MRD: 
Mrad2831_0345 Mrad2831_3921
MET: 
M446_2685 M446_6272
MPO: 
Mpop_3144 Mpop_4578
MNO: 
Mnod_4809 Mnod_6929
BID: 
Bind_0130 Bind_3036
MSL: 
Msil_1939 Msil_2957
HDN: 
Hden_2491
HMC: 
HYPMC_0949
RVA: 
Rvan_3372
MSC: 
BN69_0556 BN69_1685
SIL: 
SPOA0294(pmtA)
SIT: 
TM1040_3086
RSP: 
RSP_0721(PmtA)
RSH: 
Rsph17029_2376
RSQ: 
Rsph17025_2440
RSK: 
RSKD131_2079
RCP: 
RCAP_rcc00559(pmtA)
PDE: 
Pden_4690
DSH: 
Dshi_2712
PSF: 
PSE_0487
PGA: 
PGA1_c29610(pmtA)
PGL: 
PGA2_c27520(pmtA)
GOX: 
GOX1862
GOH: 
B932_0129
GBE: 
GbCGDNIH1_2260
ACR: 
Acry_2168
AMV: 
ACMV_24160(pmtA)
GDI: 
GDI_2102(pmtA)
GDJ: 
Gdia_0321
GXY: 
GLX_26190
APT: 
APA01_16840
APW: 
APA42C_16840
APF: 
APA03_16840
APU: 
APA07_16840
APG: 
APA12_16840
APQ: 
APA22_16840
APX: 
APA26_16840
APZ: 
APA32_16840
AZL: 
AZL_e02950
ALI: 
AZOLI_p50184
ABS: 
AZOBR_p130167 AZOBR_p280017
TMO: 
TMO_1929
PGV: 
SL003B_4324
GMC: 
GY4MC1_2270
PHM: 
PSMK_14180(pmtA)
NDE: 
NIDE0511(pmtA)
MOX: 
DAMO_1446(pmtA)
 » show all
Taxonomy
Reference
1  [PMID:25437]
  Authors
Hirata F, Viveros OH, Diliberto EJ Jr, Axelrod J.
  Title
Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 75 (1978) 1718-21.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:438165]
  Authors
Schneider WJ, Vance DE.
  Title
Conversion of phosphatidylethanolamine to phosphatidylcholine in rat liver. Partial purification and characterization of the enzymatic activities.
  Journal
J. Biol. Chem. 254 (1979) 3886-91.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
67167-73-1
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