| Entry |
|
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| Name |
3-hydroxyanthranilate 4-C-methyltransferase;
3-hydroxyanthranilate 4-methyltransferase
|
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
 |
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| Sysname |
S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase
|
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + 3-hydroxyanthranilate = S-adenosyl-L-homocysteine + 3-hydroxy-4-methylanthranilate [RN: R02667]
|
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| Reaction(KEGG) |
|
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
3-hydroxyanthranilate [CPD: C00632]
|
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
3-hydroxy-4-methylanthranilate [CPD: C03986]
|
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| Comment |
Involved in the biosynthesis of the antibiotic actinomycin in Streptomyces antibioticus.
|
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| Reference |
|
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| Authors |
Fawaz F, Jones GH. |
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| Title |
Actinomycin synthesis in Streptomyces antibioticus. Purification and properties of a 3-hydroxyanthranilate 4-methyltransferase. |
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| Journal |
J. Biol. Chem. 263 (1988) 4602-6. |
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| Organism |
Streptomyces antibioticus |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 112445-22-4 |
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