KEGG   ENZYME: 2.1.1.99Help
Entry
EC 2.1.1.99                 Enzyme                                 

Name
3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase;
16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase;
NMT;
16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase;
S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3-hydroxy-16-methoxy-2,3-dihydrotabersonine = S-adenosyl-L-homocysteine + deacetoxyvindoline [RN:R04013]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3-hydroxy-16-methoxy-2,3-dihydrotabersonine
Product
S-adenosyl-L-homocysteine [CPD:C00021];
deacetoxyvindoline [CPD:C02673]
Comment
Involved in the biosynthesis of vindoline from tabersonine in the Madagascar periwinkle Catharanthus roseus.
History
EC 2.1.1.99 created 1990, modified 2005
Pathway
Indole alkaloid biosynthesis
Reference
1
  Authors
De Luca, V., Balsevich, J., Tyler, R.T., Eilert, U., Panchuk, B.D. and Kurz, W.G.W.
  Title
Biosynthesis of indole alkaloids - developmental regulation of the biosynthetic-pathway from tabersonine to vindoline in Catharanthus roseus.
  Journal
J. Plant Physiol. 125 (1986) 147-156.
Reference
2  [PMID:16665811]
  Authors
De Luca V, Cutler AJ
  Title
Subcellular Localization of Enzymes Involved in Indole Alkaloid Biosynthesis in Catharanthus roseus.
  Journal
Plant. Physiol. 85 (1987) 1099-1102.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
113478-40-3

DBGET integrated database retrieval system