| Entry |
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| Name |
glutamate formimidoyltransferase;
glutamate formyltransferase;
formiminoglutamic acid transferase;
formiminoglutamic formiminotransferase;
glutamate formiminotransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Hydroxymethyl-, formyl- and related transferases
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| Sysname |
5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase
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| Reaction(IUBMB) |
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate [RN: R02287]
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| Reaction(KEGG) |
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| Substrate |
5-formimidoyltetrahydrofolate [CPD: C00664];
L-glutamate [CPD: C00025]
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| Product |
tetrahydrofolate [CPD: C00101];
N-formimidoyl-L-glutamate [CPD: C00439]
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| Comment |
A pyridoxal-phosphate protein. Also catalyses formyl transfer from 5-formyltetrahydrofolate to L-glutamate (a reaction formerly listed as EC 2.1.2.6). In eukaryotes, it occurs as a bifunctional enzyme that also has formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity.
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| Pathway |
| Histidine metabolism | | One carbon pool by folate | | Metabolic pathways |
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| Orthology |
| glutamate formiminotransferase | | glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | ISC: | | NVE: | | AQU: | | DDI: | | DPP: | | DPS: | | DAT: | | DTO: | | SAT: | | SPY: | | SPZ: | | SPYM: | | SPM: | | SPG: | | SPS: | | SPH: | | SPI: | | SPJ: | | SPK: | | SPF: | | SPA: | | SPB: | | STG: | | SOZ: | | STZ: | | STX: | | SPYA: | | SSA: | | SGO: | | SDS: | | SDG: | | SDA: | | SDC: | | STK: | | SCP: | | SCF: | | CTC: | | CLJ: | | CSO: | | CAD: | | CST: | | AMT: | | AOE: | | STH: | | DOR: | | DAI: | | DMI: | | OVA: | | SAY: | | SAP: | | TTE: | | TEX: | | THX: | | TPD: | | TIT: | | TMT: | | TBO: | | TWI: | | CHY: | | TEP: | | TAE: | | TPZ: | | TOC: | | TTM: | | TTO: | | TXY: | | TSH: | | CPO: | | NTH: | | HPK: | | AAR: | | AFN: | | AIN: | | CWO: | | AFO: | | TDE: | | ABA: | | ACA: | | ACM: | | GMA: | | TSA: | | TRS: | | SUS: | | CTM: | | BTH: | | BFR: | | BFS: | | BFG: | | BVU: | | BHL: | | BXY: | | PGI: | | PGN: | | PGT: | | PAH: | | PDI: | | OSP: | | TFO: | | PMZ: | | PDN: | | PIT: | | AFD: | | ASH: | | HHY: | | SGN: | | FLI: | | OHO: | | FNU: | | GAU: | | EMI: | | TAI: | | ACO: | | TLI: | | AMO: | | IAL: | | HAU: | | ATM: | | CAP: | | TMA: | | TPT: | | TLE: | | TRQ: | | TNA: | | TNP: | | TTA: | | TME: | | TAF: | | FNO: | | FPE: | | PMO: | | KOL: | | MPG: | | NDE: | | CEX: | | TTR: | | TAC: | | PTO: | | ABI: | | ACF: | |
» show all
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| Reference |
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| Authors |
MILLER A, WAELSCH H. |
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| Title |
Formimino transfer from formamidinoglutaric acid to tetrahydrofolic acid. |
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| Journal |
J. Biol. Chem. 228 (1957) 397-417. |
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| Organism |
Rattus norvegicus [GN: rno], Bos taurus [GN: bta] |
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| Reference |
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| Authors |
SILVERMAN M, KERESZTESY JC, KOVAL GJ, GARDINER RC. |
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| Title |
Citrovorum factor and the synthesis of formylglutamic acid. |
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| Journal |
J. Biol. Chem. 226 (1957) 83-94. |
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| Organism |
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| Reference |
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| Authors |
TABOR H, WYNGARDEN L. |
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| Title |
The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid. |
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| Journal |
J. Biol. Chem. 234 (1959) 1830-46. |
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| Organism |
Sus scofa [GN: ssc], Oryctolagus cuniculus |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9032-83-1 |
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