KEGG   ENZYME: 2.1.3.10Help
Entry
EC 2.1.3.10                 Enzyme                                 

Name
malonyl-S-ACP:biotin-protein carboxyltransferase;
malonyl-S-acyl-carrier protein:biotin-protein carboxyltransferase;
MadC/MadD;
MadC,D;
malonyl-[acyl-carrier protein]:biotinyl-[protein] carboxyltransferase
Class
Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases
BRITE hierarchy
Sysname
malonyl-[acyl-carrier protein]:biotinyl-[protein] carboxytransferase
Reaction(IUBMB)
a malonyl-[acyl-carrier protein] + a biotinyl-[protein] = an acetyl-[acyl-carrier protein] + a carboxybiotinyl-[protein] [RN:R08936]
Reaction(KEGG)
Substrate
malonyl-[acyl-carrier protein] [CPD:C01209];
biotinyl-[protein] [CPD:C18046]
Product
acetyl-[acyl-carrier protein] [CPD:C03939];
carboxybiotinyl-[protein] [CPD:C18047]
Comment
Derived from the components MadC and MadD of the anaerobic bacterium Malonomonas rubra, this enzyme is a component of EC 4.1.1.89, biotin-dependent malonate decarboxylase. The carboxy group is transferred from malonate to the prosthetic group of the biotin protein (MadF) with retention of configuration [2]. Similar to EC 4.1.1.87, malonyl-S-ACP decarboxylase, which forms part of the biotin-independent malonate decarboxylase (EC 4.1.1.88), this enzyme also follows on from EC 2.3.1.187, acetyl-S-ACP:malonate ACP transferase, and results in the regeneration of the acetyl-[acyl-carrier protein] [3].
History
EC 2.1.3.10 created 2008
Orthology
K20510  
malonyl-S-ACP:biotin-protein carboxyltransferase subunit MadC
K20511  
malonyl-S-ACP:biotin-protein carboxyltransferase subunit MadD
Genes
EFE: 
KPZ: 
KPB: 
CAMA: 
SFO: 
DES: 
RPB: 
RPC: 
RCP: 
RRU: 
RRF: 
ATI: 
PFT: 
 » show all
Taxonomy
Reference
1  [PMID:9128730]
  Authors
Berg M, Hilbi H, Dimroth P
  Title
Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function.
  Journal
Eur. J. Biochem. 245 (1997) 103-15.
  Sequence
Reference
2
  Authors
Micklefield, J., Harris, K.J., Groger, S., Mocek, U., Hilbi, H., Dimroth, P. and Floss, H.G.
  Title
Stereochemical course of malonate decarboxylase in Malonomonas rubra has biotin decarboxylation with retention.
  Journal
J. Am. Chem. Soc. 117 (1995) 1153-1154.
Reference
3  [PMID:11902724]
  Authors
Dimroth P, Hilbi H
  Title
Enzymic and genetic basis for bacterial growth on malonate.
  Journal
Mol. Microbiol. 25 (1997) 3-10.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system