KEGG   ENZYME: 2.1.3.11Help
Entry
EC 2.1.3.11                 Enzyme                                 

Name
N-succinylornithine carbamoyltransferase;
succinylornithine transcarbamylase;
N-succinyl-L-ornithine transcarbamylase;
SOTCase
Class
Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases
BRITE hierarchy
Sysname
carbamoyl phosphate:N2-succinyl-L-ornithine carbamoyltransferase
Reaction(IUBMB)
carbamoyl phosphate + N2-succinyl-L-ornithine = phosphate + N-succinyl-L-citrulline [RN:R08937]
Reaction(KEGG)
Substrate
carbamoyl phosphate [CPD:C00169];
N2-succinyl-L-ornithine [CPD:C03415]
Product
phosphate [CPD:C00009];
N-succinyl-L-citrulline [CPD:C18048]
Comment
This enzyme is specific for N-succinyl-L-ornithine and cannot use either L-ornithine (see EC 2.1.3.3, ornithine carbamoyltransferase) or N-acetyl-L-ornithine (see EC 2.1.3.9, N-acetylornithine carbamoyltransferase) as substrate. However, a single amino-acid substitution (Pro90 -> Glu90) is sufficient to switch the enzyme to one that uses N-acetyl-L-ornithine as substrate. It is essential for de novo arginine biosynthesis in the obligate anaerobe Bacteroides fragilis, suggesting that this organism uses an alternative pathway for synthesizing arginine.
History
EC 2.1.3.11 created 2008
Orthology
K13043  
N-succinyl-L-ornithine transcarbamylase
Genes
BTH: 
BFR: 
BFS: 
BFG: 
BFB: 
BVU: 
BHL: 
BSA: 
BXY: 
BDO: 
BDH: 
BOA: 
BCEL: 
BACC: 
PDI: 
PPN: 
TFO: 
BFO_2797(argF')
BVS: 
PBT: 
APS: 
PRU: 
PDT: 
AFD: 
ASH: 
DOI: 
CPI: 
NKO: 
NSO: 
HHY: 
PHE: 
PEP: 
PSN: 
SHG: 
SHT: 
SCN: 
CMR: 
CAMU: 
BBD: 
EVI: 
CHU: 
CHU_3085(argF)
DFE: 
SLI: 
SRD: 
LBY: 
RSI: 
FLI: 
EOL: 
FAE: 
HSW: 
HYM: 
HYD: 
HYE: 
HYG: 
PKO: 
RUF: 
RTI: 
MTT: 
FBT: 
GFO: 
GFO_2103(argF)
FJO: 
FBR: 
FCO: 
RBI: 
ZPR: 
FBC: 
CAO: 
CLY: 
CLH: 
CBAL: 
CBAT: 
WVI: 
KDI: 
DOK: 
DDO: 
I597_1160(argF')
LAN: 
ZGA: 
MRS: 
MLT: 
PTQ: 
POM: 
EAO: 
EMN: 
ELB: 
VO54_02834(argF')
MYR: 
MPW: 
MOD: 
CHZ: 
CHSO_1869(argF)
CGN: 
WIN: 
SZE: 
AHZ: 
SYI: 
LUT: 
FBA: 
SMG: 
SMS: 
SMH: 
SUM: 
SMV: 
SMUB: 
SMUM: 
SMUE: 
SMUP: 
BBL: 
BPI: 
BPLAN_322(argF)
BMM: 
MADAR_053(argF)
BCP: 
BBG: 
BGIGA_315(argF)
BBQ: 
BLP: 
BPAA_326(argF)
BLU: 
OHO: 
UDI: 
ASNER_235(argF)
 » show all
Taxonomy
Reference
1  [PMID:16704984]
  Authors
Shi D, Morizono H, Cabrera-Luque J, Yu X, Roth L, Malamy MH, Allewell NM, Tuchman M
  Title
Structure and catalytic mechanism of a novel N-succinyl-L-ornithine transcarbamylase in arginine biosynthesis of Bacteroides fragilis.
  Journal
J. Biol. Chem. 281 (2006) 20623-31.
  Sequence
Reference
2  [PMID:17600144]
  Authors
Shi D, Yu X, Cabrera-Luque J, Chen TY, Roth L, Morizono H, Allewell NM, Tuchman M
  Title
A single mutation in the active site swaps the substrate specificity of N-acetyl-L-ornithine transcarbamylase and N-succinyl-L-ornithine transcarbamylase.
  Journal
Protein. Sci. 16 (2007) 1689-99.
  Sequence
[bfr:BF0494]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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