KEGG   ENZYME: 2.1.3.12Help
Entry
EC 2.1.3.12                 Enzyme                                 

Name
decarbamoylnovobiocin carbamoyltransferase;
novN (gene name)
Class
Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases
BRITE hierarchy
Sysname
carbamoyl phosphate:decarbamoylnovobiocin 3''-O-carbamoyltransferase
Reaction(IUBMB)
carbamoyl phosphate + decarbamoylnovobiocin = phosphate + novobiocin [RN:R06772]
Reaction(KEGG)
Substrate
carbamoyl phosphate [CPD:C00169];
decarbamoylnovobiocin [CPD:C12476]
Product
phosphate [CPD:C00009];
novobiocin [CPD:C05080]
Comment
The enzyme catalyses the last step in the biosynthesis of the aminocoumarin antibiotic novobiocin. The reaction is activated by ATP [1].
History
EC 2.1.3.12 created 2013
Pathway
Novobiocin biosynthesis
Biosynthesis of antibiotics
Orthology
K12713  
decarbamoylnovobiocin carbamoyltransferase
Reference
1  [PMID:14694473]
  Authors
Freel Meyers CL, Oberthur M, Xu H, Heide L, Kahne D, Walsh CT
  Title
Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring.
  Journal
Angew. Chem. Int. Ed. Engl. 43 (2004) 67-70.
  Sequence
Reference
2  [PMID:18997325]
  Authors
Gomez Garcia I, Freel Meyers CL, Walsh CT, Lawson DM
  Title
Crystallization and preliminary X-ray analysis of the O-carbamoyltransferase NovN from the novobiocin-biosynthetic cluster of Streptomyces spheroides.
  Journal
Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 64 (2008) 1000-2.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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