KEGG   ENZYME: 2.1.3.7Help
Entry
EC 2.1.3.7                  Enzyme                                 

Name
3-hydroxymethylcephem carbamoyltransferase
Class
Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases
BRITE hierarchy
Sysname
carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase
Reaction(IUBMB)
carbamoyl phosphate + a 3-hydroxymethylceph-3-em-4-carboxylate = phosphate + a 3-carbamoyloxymethylcephem [RN:R04281]
Reaction(KEGG)
Substrate
carbamoyl phosphate [CPD:C00169];
3-hydroxymethylceph-3-em-4-carboxylate
Product
phosphate [CPD:C00009];
3-carbamoyloxymethylcephem [CPD:C03674]
Comment
Acts on a wide range of 3-hydroxymethylcephems (a subclass of the cephalosporin antibiotics). Activated by ATP.
History
EC 2.1.3.7 created 1983
Pathway
Penicillin and cephalosporin biosynthesis
Biosynthesis of antibiotics
Orthology
K04128  
hydroxymethyl cephem carbamoyltransferase
Genes
YEE: 
YAL: 
RSO: 
RSp1487(cmcH)
RSL: 
RSN: 
RSE: 
BGF: 
BGD: 
RFR: 
REL: 
SWI: 
SCT: 
SCAT_5682(cmcH)
SCY: 
AOI: 
AORI_3162(cmcH)
AJA: 
ALU: 
MIL: 
 » show all
Taxonomy
Reference
1  [PMID:6248024]
  Authors
Brewer SJ, Taylor PM, Turner MK.
  Title
An adenosine triphosphate-dependent carbamoylphosphate--3-hydroxymethylcephem O-carbamoyltransferase from Streptomyces clavuligerus.
  Journal
Biochem. J. 185 (1980) 555-64.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
74315-96-1

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