KEGG   ENZYME: 2.1.3.7Help
Entry
EC 2.1.3.7                  Enzyme                                 

Name
3-hydroxymethylcephem carbamoyltransferase
Class
Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases
BRITE hierarchy
Sysname
carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase
Reaction(IUBMB)
carbamoyl phosphate + a 3-hydroxymethylceph-3-em-4-carboxylate = phosphate + a 3-carbamoyloxymethylcephem [RN:R04281]
Reaction(KEGG)
Substrate
carbamoyl phosphate [CPD:C00169];
3-hydroxymethylceph-3-em-4-carboxylate
Product
phosphate [CPD:C00009];
3-carbamoyloxymethylcephem [CPD:C03674]
Comment
Acts on a wide range of 3-hydroxymethylcephems (a subclass of the cephalosporin antibiotics). Activated by ATP.
History
EC 2.1.3.7 created 1983
Pathway
ec00311  Penicillin and cephalosporin biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K04128  hydroxymethyl cephem carbamoyltransferase
Genes
YEE: YE5303_29981
YAL: AT01_3057
RSO: RSp1487(cmcH)
RSL: RPSI07_2714 RPSI07_mp0876(cmcH)
RSN: RSPO_m00518
RSE: F504_4958
BGF: BC1003_2995
BGD: bgla_4p2750
RFR: Rfer_3660
REL: REMIM1_PE00060(cmcH)
SWI: Swit_4991
SCT: SCAT_5682(cmcH)
AOI: AORI_3162(cmcH)
AJA: AJAP_23550(cmcH)
MIL: ML5_4153
 » show all
Taxonomy
Reference
1  [PMID:6248024]
  Authors
Brewer SJ, Taylor PM, Turner MK.
  Title
An adenosine triphosphate-dependent carbamoylphosphate--3-hydroxymethylcephem O-carbamoyltransferase from Streptomyces clavuligerus.
  Journal
Biochem. J. 185 (1980) 555-64.
Other DBs
ExplorEnz - The Enzyme Database: 2.1.3.7
IUBMB Enzyme Nomenclature: 2.1.3.7
ExPASy - ENZYME nomenclature database: 2.1.3.7
BRENDA, the Enzyme Database: 2.1.3.7
CAS: 74315-96-1

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