KEGG   ENZYME: 2.2.1.8Help
Entry
EC 2.2.1.8                  Enzyme                                 

Name
fluorothreonine transaldolase
Class
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
BRITE hierarchy
Sysname
fluoroacetaldehyde:L-threonine aldehydetransferase
Reaction(IUBMB)
L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine [RN:R07247]
Reaction(KEGG)
Substrate
L-threonine [CPD:C00188];
fluoroacetaldehyde [CPD:C15488]
Product
acetaldehyde [CPD:C00084];
4-fluoro-L-threonine [CPD:C15533]
Comment
A pyridoxal phosphate protein. Can also convert chloroacetaldehyde into4-chloro-L-threonine. Unlike EC 2.1.2.1, glycine hydroxymethyltransferase, does not use glycine as a substrate.
History
EC 2.2.1.8 created 2003
Reference
1  [PMID:12404452]
  Authors
Murphy CD, O'Hagan D, Schaffrath C.
  Title
Identification of a PLP-Dependent Threonine Transaldolase: A Novel Enzyme Involved in 4-Fluorothreonine Biosynthesis in Streptomyces cattleya This work was supported by the Biotechnological and Biological Sciences Research Council and the University of St Andrews.
  Journal
Angew. Chem. Int. Ed. Engl. 40 (2001) 4479-4481.
  Organism
Streptomyces cattleya
Reference
2  [PMID:12738270]
  Authors
Murphy CD, Schaffrath C, O'Hagan D.
  Title
Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya.
  Journal
Chemosphere. 52 (2003) 455-61.
  Organism
Streptomyces cattleya
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
403503-13-9

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