KEGG   ENZYME: 2.3.1.111Help
Entry
EC 2.3.1.111                Enzyme                                 
Name
mycocerosate synthase;
mycocerosic acid synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)
Reaction(IUBMB)
acyl-CoA + n methylmalonyl-CoA + 2n NADPH + 2n H+ = multi-methyl-branched acyl-CoA + n CoA + n CO2 + 2n NADP+ [RN:R05189]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
methylmalonyl-CoA [CPD:C02557];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
multi-methyl-branched acyl-CoA [CPD:C04013];
CoA [CPD:C00010];
CO2 [CPD:C00011];
NADP+ [CPD:C00006]
Comment
The enzyme elongates CoA esters of fatty acids from C6 to C20 by incorporation of methylmalonyl, but not malonyl, residues, to form multimethyl-branched fatty-acyl-CoAs such as 2,4,6,8-tetramethyl-octanoyl-CoA.
Orthology
K11628  
mycocerosic acid synthase
Genes
MTU: 
Rv2940c(mas)
MTV: 
MTC: 
MT3010(mas-2)
MRA: 
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTE: 
MTL: 
CCDC5180_2664
MTO: 
MTCTRI2_2997(mas)
MTD: 
UDA_2940c(mas)
MBO: 
Mb2965c(mas)
MBB: 
BCG_2962c(mas)
MBT: 
JTY_2957(mas)
MBM: 
BCGMEX_2957c(mas)
MAF: 
MAF_29450(mas)
MCE: 
MCAN_29621(mas)
MCV: 
BN43_40648(mas)
MCX: 
BN42_40938(mas)
MCZ: 
BN45_51352(mas)
MLE: 
ML0139(mas)
MLB: 
MLBr_00139(mas)
MUL: 
MUL_2010(mas)
MMI: 
MMAR_1767(mas)
MLI: 
MULP_01923(mas)
 » show all
Taxonomy
Reference
1  [PMID:3880746]
  Authors
Rainwater DL, Kolattukudy PE.
  Title
Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guerin. Purification and characterization of a novel fatty acid synthase, mycocerosic acid synthase, which elongates n-fatty acyl-CoA with methylmalonyl-CoA.
  Journal
J. Biol. Chem. 260 (1985) 616-23.
  Organism
Mycobacterium tuberculosis
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
95229-19-9
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