KEGG   ENZYME: 2.3.1.136Help
Entry
EC 2.3.1.136                Enzyme                                 

Name
polysialic-acid O-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:polysialic-acid O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9 [RN:R04484 R07249]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
alpha-2,8-linked polymer of sialic acid [CPD:C04466]
Product
CoA [cpd:C00010];
polysialic acid acetylated at O-7 [CPD:C04505];
polysialic acid acetylated at O-9 [CPD:C08721]
Comment
Acts only on substrates containing more than 14 sialosyl residues. Catalyses the modification of capsular polysaccharides in some strains of Escherichia coli.
History
EC 2.3.1.136 created 1992
Reference
1  [PMID:2897964]
  Authors
Higa HH, Varki A.
  Title
Acetyl-coenzyme A:polysialic acid O-acetyltransferase from K1-positive Escherichia coli. The enzyme responsible for the O-acetyl plus phenotype and for O-acetyl form variation.
  Journal
J. Biol. Chem. 263 (1988) 8872-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
116412-21-6

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