KEGG   ENZYME: 2.3.1.140Help
Entry
EC 2.3.1.140                Enzyme                                 

Name
rosmarinate synthase;
rosmarinic acid synthase;
caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase;
4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase;
RAS (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
caffeoyl-CoA:(R)-3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase
Reaction(IUBMB)
caffeoyl-CoA + (R)-3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate [RN:R03374]
Reaction(KEGG)
Substrate
caffeoyl-CoA [CPD:C00323];
(R)-3-(3,4-dihydroxyphenyl)lactate
Product
CoA [CPD:C00010];
rosmarinate [CPD:C01850]
Comment
Involved, with EC 1.1.1.237 (hydroxyphenylpyruvate reductase) in the biosynthesis of rosmarinic acid. Characterized from the plant Melissa officinalis L. (lemon balm).
History
EC 2.3.1.140 created 1992, modified 2013
Pathway
Tyrosine metabolism
Reference
1
  Authors
Petersen, M. and Alfermann, A.W.
  Title
Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase.
  Journal
Z. Naturforsch. C: Biosci. 43 (1988) 501-504.
Reference
2
  Authors
Petersen, M. S.
  Title
Characterization of rosmarinic acid synthase from cell cultures of Coleus blumei.
  Journal
Phytochemistry 30 (1991) 2877-2881.
Reference
3  [PMID:21354582]
  Authors
Weitzel C, Petersen M
  Title
Cloning and characterisation of rosmarinic acid synthase from Melissa officinalis L.
  Journal
Phytochemistry. 72 (2011) 572-8.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
117590-80-4

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