KEGG   ENZYME: 2.3.1.148Help
Entry
EC 2.3.1.148                Enzyme                                 

Name
glycerophospholipid acyltransferase (CoA-dependent)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent)
Reaction(IUBMB)
1-organyl-2-acyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine = 1-organyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-organyl-2-lyso-sn-glycero-3-phosphocholine [RN:R04721]
Reaction(KEGG)
Substrate
1-organyl-2-acyl-sn-glycero-3-phosphocholine [CPD:C05212];
1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine [CPD:C05209]
Product
1-organyl-2-acyl-sn-glycero-3-phosphoethanolamine [CPD:C04475];
1-organyl-2-lyso-sn-glycero-3-phosphocholine [CPD:C04317]
Comment
Catalyses the transfer of fatty acids from intact choline- or ethanolamine-containing glycerophospholipids to the sn-2 position of a lyso-glycerophospholipid. The organyl group on sn-1 of the donor or acceptor molecule can be alkyl, acyl or alk-1-enyl. The term 'radyl' has sometimes been used to refer to such substituting groups. Differs from EC 2.3.1.147 glycerophospholipid arachidonoyl-transferase (CoA-independent) in requiring CoA and not favouring the transfer of polyunsaturated acyl groups.
History
EC 2.3.1.148 created 1999
Reference
1  [PMID:526311]
  Authors
Irvine RF, Dawson RM.
  Title
Transfer of arachidonic acid between phospholipids in rat liver microsomes.
  Journal
Biochem. Biophys. Res. Commun. 91 (1979) 1399-405.
Reference
2  [PMID:4008481]
  Authors
Robinson M, Blank ML, Snyder F.
  Title
Acylation of lysophospholipids by rabbit alveolar macrophages. Specificities of CoA-dependent and CoA-independent reactions.
  Journal
J. Biol. Chem. 260 (1985) 7889-95.
Reference
3  [PMID:1641397]
  Authors
Snyder F, Lee TC, Blank ML.
  Title
The role of transacylases in the metabolism of arachidonate and platelet activating factor.
  Journal
Prog. Lipid. Res. 31 (1992) 65-86.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9054-54-0

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