KEGG   ENZYME: 2.3.1.149Help
Entry
EC 2.3.1.149                Enzyme                                 

Name
platelet-activating factor acetyltransferase;
PAF acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phospholipid acetyltransferase
Reaction(IUBMB)
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-organyl-2-acetyl-sn-glycero-3-phospholipid [RN:R04722]
Reaction(KEGG)
Substrate
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine;
1-organyl-2-lyso-sn-glycero-3-phospholipid [CPD:C05217]
Product
1-alkyl-2-lyso-sn-glycero-3-phosphocholine [CPD:C04317];
1-organyl-2-acetyl-sn-glycero-3-phospholipid [CPD:C05218]
Comment
Catalyses the transfer of the acetyl group from 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) to the sn-2 position of lyso-glycerophospholipids containing ethanolamine, choline, serine, inositol or phosphate groups at the sn-3 position as well as to sphingosine and long-chain fatty alcohols. The organyl group can be alkyl, acyl or alk-1-enyl (sometimes also collectively referred to as 'radyl').
History
EC 2.3.1.149 created 1999
Reference
1  [PMID:1400315]
  Authors
Lee TC, Uemura Y, Snyder F.
  Title
A novel CoA-independent transacetylase produces the ethanolamine plasmalogen and acyl analogs of platelet-activating factor (PAF) with PAF as the acetate donor in HL-60 cells.
  Journal
J. Biol. Chem. 267 (1992) 19992-20001.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9012-30-0

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