KEGG   ENZYME: 2.3.1.150Help
Entry
EC 2.3.1.150                Enzyme                                 
Name
salutaridinol 7-O-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:salutaridinol 7-O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + salutaridinol = CoA + 7-O-acetylsalutaridinol [RN:R04723]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
salutaridinol [CPD:C05220]
Product
CoA [CPD:C00010];
7-O-acetylsalutaridinol [CPD:C05322]
Comment
The enzyme is present in the poppy, Papaver somniferum. At pH 8-9 the product, 7-O-acetylsalutaridinol, spontaneously closes the 4->5 oxide bridge by allylic elimination to form the morphine precursor thebaine
Pathway
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K13393  
salutaridinol 7-O-acetyltransferase
Reference
1
  Authors
Lenz, R., Zenk, M.H.
  Title
Closure of the oxide bridge in morphine biosynthesis.
  Journal
Tetrahedron Lett. 35 (1994) 3897-3900.
Reference
2  [PMID:8537369]
  Authors
Lenz R, Zenk MH.
  Title
Acetyl coenzyme A:salutaridinol-7-O-acetyltransferase from papaver somniferum plant cell cultures. The enzyme catalyzing the formation of thebaine in morphine biosynthesis.
  Journal
J. Biol. Chem. 270 (1995) 31091-6.
  Organism
Papaver somniferum
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
156859-13-1
DBGET integrated database retrieval system