| Entry |
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| Name |
propionyl-CoA C2-trimethyltridecanoyltransferase;
3-oxopristanoyl-CoA hydrolase;
3-oxopristanoyl-CoA thiolase;
peroxisome sterol carrier protein thiolase;
sterol carrier protein;
oxopristanoyl-CoA thiolase;
peroxisomal 3-oxoacyl coenzyme A thiolase;
SCPx;
4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
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| Sysname |
4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA C2-4,8,12-trimethyltridecanoyltransferase
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| Reaction(IUBMB) |
4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = CoA + 3-oxopristanoyl-CoA [RN: R05330]
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| Reaction(KEGG) |
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| Substrate |
4,8,12-trimethyltridecanoyl-CoA [CPD: C07296];
propanoyl-CoA [CPD: C00100]
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| Product |
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| Comment |
The peroxisomal protein sterol carrier protein X (SCPx) combines this thiolase activity with its carrier function, and is involved in branched chain fatty acid beta-oxidation in peroxisomes. It also acts on 3-oxopalmitoyl-CoA as a substrate but differs from EC 2.3.1.16 (acetyl-CoA C-acyltransferase), which has little activity towards the 3-oxoacyl-CoA esters of 2-methyl-branched chain fatty acids such as 3-oxopristanoyl-CoA.
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| Reference |
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| Authors |
Seedorf U, Brysch P, Engel T, Schrage K, Assmann G. |
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| Title |
Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity. |
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| Journal |
J. Biol. Chem. 269 (1994) 21277-83. |
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| Organism |
Homo sapiens [GN: hsa], Mus musculus [GN: mmu], Rattus norvegicus [GN: rno] |
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| Reference |
|
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| Authors |
Wanders RJ, Denis S, Wouters F, Wirtz KW, Seedorf U. |
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| Title |
Sterol carrier protein X (SCPx) is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: a new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes. |
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| Journal |
Biochem. Biophys. Res. Commun. 236 (1997) 565-9. |
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| Organism |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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