KEGG   ENZYME: 2.3.1.159Help
Entry
EC 2.3.1.159                Enzyme                                 

Name
acridone synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)
Reaction(IUBMB)
3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2 [RN:R07250]
Reaction(KEGG)
Substrate
malonyl-CoA [CPD:C00083];
N-methylanthraniloyl-CoA [CPD:C12092]
Product
CoA [CPD:C00010];
1,3-dihydroxy-N-methylacridone [CPD:C12093];
CO2 [CPD:C00011]
Comment
Belongs to a superfamily of plant polyketide synthases. Has many similarities to chalcone and stilbene synthases (see reaction synthesis)
History
EC 2.3.1.159 created 2002
Pathway
Acridone alkaloid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K12644  
acridone synthase
Genes
CIT: 
CIC: 
Taxonomy
Reference
1  [PMID:8148006]
  Authors
Baumert A, Maier W, Groger D, Deutzmann R.
  Title
Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L.
  Journal
Z. Naturforsch. [C]. 49 (1994) 26-32.
Reference
2
  Authors
Maier, W., Baumert, A., Schumann, B., Furukawa, H. and Groger, D.
  Title
Synthesis of 1,3-dihydroxy-N-methylacridone and its conversion to rutacridone by cell-free extracts of Ruta-graveolens cell cultures.
  Journal
Phytochemistry 32 (1993) 691-698.
Reference
3  [PMID:10217426]
  Authors
Lukacin R, Springob K, Urbanke C, Ernwein C, Schroder G, Schroder J, Matern U.
  Title
Native acridone synthases I and II from Ruta graveolens L. form homodimers.
  Journal
FEBS. Lett. 448 (1999) 135-40.
  Sequence
Reference
4  [PMID:9747538]
  Authors
Junghanns KT, Kneusel RE, Groger D, Matern U.
  Title
Differential regulation and distribution of acridone synthase in Ruta graveolens.
  Journal
Phytochemistry. 49 (1998) 403-11.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
99085-53-7

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