KEGG   ENZYME: 2.3.1.165Help
Entry
EC 2.3.1.165                Enzyme                                 

Name
6-methylsalicylic-acid synthase;
MSAS;
6-methylsalicylic acid synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)
Reaction(IUBMB)
acetyl-CoA + 3 malonyl-CoA + NADPH + H+ = 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+ + H2O [RN:R07253]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
6-methylsalicylate [CPD:C02657];
CoA [CPD:C00010];
CO2 [CPD:C00011];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A multienzyme complex with a 4'-phosphopantetheine prosthetic group on the acyl carrier protein. It has a similar sequence to vertebrate type I fatty acid synthase. Acetoacetyl-CoA can also act as a starter molecule.
History
EC 2.3.1.165 created 2002
Orthology
K15320  
6-methylsalicylic acid synthase
Genes
AOR: 
AOR_1_130044(AO090206000074)
ANG: 
ANI_1_136174(An10g00140)
ACT: 
PCS: 
ABE: 
TVE: 
PNO: 
MVA: 
MGI: 
MSP: 
MMC: 
MKM: 
MJL: 
MJD: 
FRE: 
SEN: 
SAQ: 
VMA: 
 » show all
Taxonomy
Reference
1  [PMID:1471999]
  Authors
Spencer JB, Jordan PM.
  Title
Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum.
  Journal
Biochem. J. 288 ( Pt 3) (1992) 839-46.
Reference
2  [PMID:8823160]
  Authors
Child CJ, Spencer JB, Bhogal P, Shoolingin-Jordan PM.
  Title
Structural similarities between 6-methylsalicylic acid synthase from Penicillium patulum and vertebrate type I fatty acid synthase: evidence from thiol modification studies.
  Journal
Biochemistry. 35 (1996) 12267-74.
Reference
3  [PMID:10935930]
  Authors
Richardson MT, Pohl NL, Kealey JT, Khosla C.
  Title
Tolerance and specificity of recombinant 6-methylsalicyclic acid synthase.
  Journal
Metab. Eng. 1 (1999) 180-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9045-37-8

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