KEGG   ENZYME: 2.3.1.176Help
Entry
EC 2.3.1.176                Enzyme                                 
Name
propanoyl-CoA C-acyltransferase;
peroxisomal thiolase 2;
sterol carrier protein-chi;
SCPchi;
PTE-2 (ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase
Reaction(IUBMB)
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA [RN:R03719]
Reaction(KEGG)
Substrate
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA [CPD:C01794];
propanoyl-CoA [CPD:C00100]
Product
CoA [CPD:C00010];
3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA [CPD:C05467]
Comment
Also acts on dihydroxy-5beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives. The enzyme catalyses the penultimate step in the formation of bile acids. The bile acid moiety is transferred from the acyl-CoA thioester (RCO-SCoA) to either glycine or taurine (NH2R') by EC 2.3.1.65, bile acid-CoA:amino acid N-acyltransferase [4].
Pathway
Primary bile acid biosynthesis
Metabolic pathways
Orthology
K08764  
sterol carrier protein 2
Genes
HSA: 
6342(SCP2)
PTR: 
456862(SCP2)
PPS: 
100986541(SCP2)
GGO: 
101143883(SCP2)
PON: 
100173072(SCP2)
MCC: 
MMU: 
20280(Scp2)
RNO: 
25541(Scp2)
CFA: 
479564(SCP2)
FCA: 
101093036(SCP2)
BTA: 
508918(SCP2)
SSC: 
397439(SCP2)
ECB: 
100061338
MDO: 
100017946
SHR: 
100922562(SCP2)
OAA: 
100084202 100087136
GGA: 
396550(SCP2)
MGP: 
100541979
TGU: 
100218387(SCP2)
ACS: 
100559527
XLA: 
494715(scp2)
XTR: 
548512(scp2)
DRE: 
393839(scp2a)
TRU: 
101069006
OLA: 
101175107
BFO: 
BRAFLDRAFT_99780
CIN: 
100180802
SPU: 
576367
DME: 
Dmel_CG17320(ScpX) Dmel_CG17597
DPO: 
Dpse_GA25964
DAN: 
Dana_GF14486 Dana_GF15421
DER: 
Dere_GG21137 Dere_GG21682
DPE: 
Dper_GL18687 Dper_GL18688 Dper_GL19449
DSE: 
Dsec_GM17061 Dsec_GM17298
DSI: 
Dsim_GD21807 Dsim_GD24161
DWI: 
Dwil_GK15532 Dwil_GK15533
DYA: 
Dyak_GE12703 Dyak_GE13211
DGR: 
Dgri_GH10548 Dgri_GH11197
DMO: 
Dmoj_GI18118 Dmoj_GI20976
DVI: 
Dvir_GJ16125 Dvir_GJ17742
AGA: 
AgaP_AGAP007921
AAG: 
AaeL_AAEL002687
CQU: 
CpipJ_CPIJ004370
AME: 
408904
NVI: 
100123951(NV10335)
TCA: 
657233(Scpx)
API: 
100161454
PHU: 
Phum_PHUM035680
ISC: 
IscW_ISCW022661
CEL: 
CELE_Y57A10C.6(daf-22)
CBR: 
CBG20965
BMY: 
Bm1_53275
NVE: 
NEMVE_v1g207642
HMG: 
100208487
TAD: 
TRIADDRAFT_59384
YLI: 
YALI0D00176g
NCR: 
NCU03372
SMP: 
SMAC_08249
PAN: 
PODANSg6465
TTT: 
THITE_2123390
MTM: 
MYCTH_2311684
MGR: 
MGG_02409
FGR: 
FG10853.1
NHE: 
NECHADRAFT_80031
SSL: 
SS1G_10890
BFU: 
BC1G_03902
ANI: 
AN4353.2
NFI: 
NFIA_109770
AFM: 
AFUA_4G06380
AOR: 
AOR_1_1692144(AO090023000951)
ANG: 
ANI_1_216184(An04g00740)
AFV: 
AFLA_113580
ACT: 
ACLA_045690
PCS: 
Pc22g17070
CIM: 
CIMG_02988 CIMG_04177
CPW: 
CPC735_000370 CPC735_002460
PBL: 
PAAG_04374
URE: 
UREG_05610
ABE: 
ARB_01676
TVE: 
TRV_00032
AJE: 
HCAG_08974
PNO: 
SNOG_05110
PTE: 
PTT_11137
ZTR: 
MYCGRDRAFT_97115
TML: 
GSTUM_00003170001
LBC: 
LACBIDRAFT_243443
CCI: 
CC1G_13192
SCM: 
SCHCODRAFT_67156
TET: 
TTHERM_00195860
PTM: 
GSPATT00007456001 GSPATT00019162001
 » show all
Taxonomy
Reference
1  [PMID:7461136]
  Authors
Pedersen JI, Gustafsson J.
  Title
Conversion of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid into cholic acid by rat liver peroxisomes.
  Journal
FEBS. Lett. 121 (1980) 345-8.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:6668450]
  Authors
Kase F, Bjorkhem I, Pedersen JI.
  Title
Formation of cholic acid from 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes.
  Journal
J. Lipid. Res. 24 (1983) 1560-7.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:12543708]
  Authors
Russell DW.
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu. Rev. Biochem. 72 (2003) 137-74.
  Organism
Mus musculus [GN:mmu], Rattus norvegicus [GN:rno]
Reference
4  [PMID:8034703]
  Authors
Falany CN, Johnson MR, Barnes S, Diasio RB.
  Title
Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.
  Journal
J. Biol. Chem. 269 (1994) 19375-9.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
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