KEGG   ENZYME: 2.3.1.176Help
Entry
EC 2.3.1.176                Enzyme                                 

Name
propanoyl-CoA C-acyltransferase;
peroxisomal thiolase 2;
sterol carrier protein-chi;
SCPchi;
PTE-2 (ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase
Reaction(IUBMB)
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA [RN:R03719]
Reaction(KEGG)
Substrate
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA [CPD:C01794];
propanoyl-CoA [CPD:C00100]
Product
CoA [CPD:C00010];
3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA [CPD:C05467]
Comment
Also acts on dihydroxy-5beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives. The enzyme catalyses the penultimate step in the formation of bile acids. The bile acid moiety is transferred from the acyl-CoA thioester (RCO-SCoA) to either glycine or taurine (NH2R') by EC 2.3.1.65, bile acid-CoA:amino acid N-acyltransferase [4].
History
EC 2.3.1.176 created 2005
Pathway
Primary bile acid biosynthesis
Metabolic pathways
Orthology
K08764  
sterol carrier protein 2
Genes
HSA: 
6342(SCP2)
PTR: 
456862(SCP2)
PPS: 
100986541(SCP2)
GGO: 
101143883(SCP2)
PON: 
100173072(SCP2)
MCC: 
MCF: 
102140312(SCP2)
MMU: 
20280(Scp2)
RNO: 
25541(Scp2)
CGE: 
100757558(Scp2)
HGL: 
101705283(Scp2)
TUP: 
102487249(SCP2)
CFA: 
479564(SCP2)
FCA: 
101093036(SCP2)
PTG: 
102951550(SCP2)
BTA: 
508918(SCP2)
BOM: 
PHD: 
CHX: 
SSC: 
397439(SCP2)
CFR: 
ECB: 
100061338(SCP2)
MYB: 
102242920(SCP2)
MYD: 
102765227(SCP2)
PALE: 
102884769(SCP2)
MDO: 
SHR: 
100922562(SCP2)
OAA: 
GGA: 
396550(SCP2)
MGP: 
TGU: 
100218387(SCP2)
FAB: 
101820874(SCP2)
PHI: 
102105546(SCP2)
APLA: 
101803933(SCP2)
FPG: 
101913645(SCP2)
FCH: 
102053527(SCP2)
CLV: 
102087499(SCP2)
ASN: 
102377979(SCP2)
PSS: 
102461487(SCP2)
CMY: 
ACS: 
XLA: 
494715(scp2)
XTR: 
548512(scp2)
DRE: 
393839(scp2a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
408904(GB10657)
NVI: 
TCA: 
657233(Scpx)
BMOR: 
692782(Scpx)
API: 
PHU: 
ISC: 
CEL: 
CBR: 
BMY: 
LOA: 
NVE: 
HMG: 
TAD: 
YLI: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
TRE: 
SSL: 
BFU: 
ANI: 
NFI: 
AFM: 
AOR: 
AOR_1_1692144(AO090023000951)
ANG: 
ANI_1_216184(An04g00740)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
LBC: 
CCI: 
SCM: 
ACAN: 
TET: 
PTM: 
 » show all
Taxonomy
Reference
1  [PMID:7461136]
  Authors
Pedersen JI, Gustafsson J.
  Title
Conversion of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid into cholic acid by rat liver peroxisomes.
  Journal
FEBS. Lett. 121 (1980) 345-8.
  Organism
Rattus norvegicus
Reference
2  [PMID:6668450]
  Authors
Kase F, Bjorkhem I, Pedersen JI.
  Title
Formation of cholic acid from 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes.
  Journal
J. Lipid. Res. 24 (1983) 1560-7.
  Organism
Rattus norvegicus
Reference
3  [PMID:12543708]
  Authors
Russell DW.
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu. Rev. Biochem. 72 (2003) 137-74.
  Organism
Mus musculus, Rattus norvegicus
Reference
4  [PMID:8034703]
  Authors
Falany CN, Johnson MR, Barnes S, Diasio RB.
  Title
Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.
  Journal
J. Biol. Chem. 269 (1994) 19375-9.
  Organism
Homo sapiens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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