KEGG   ENZYME: 2.3.1.186Help
Entry
EC 2.3.1.186                Enzyme                                 

Name
pseudotropine acyltransferase;
pseudotropine:acyl-CoA transferase;
tigloyl-CoA:pseudotropine acyltransferase;
acetyl-CoA:pseudotropine acyltransferase;
pseudotropine acetyltransferase;
pseudotropine tigloyltransferase;
PAT
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:pseudotropine O-acyltransferase
Reaction(IUBMB)
an acyl-CoA + pseudotropine = CoA + an O-acylpseudotropine [RN:R08713]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
pseudotropine [CPD:C02066]
Product
CoA [CPD:C00010];
O-acylpseudotropine [CPD:C17378]
Comment
This enzyme exhibits absolute specificity for the exo/3beta configuration found in pseudotropine as tropine (tropan-3alpha-ol; see EC 2.3.1.185, tropine acyltransferase) and nortropine are not substrates [1]. Acts on a wide range of aliphatic acyl-CoA derivatives, including acetyl-CoA, beta-methylcrotonyl-CoA and tigloyl-CoA [1].
History
EC 2.3.1.186 created 2008
Pathway
Tropane, piperidine and pyridine alkaloid biosynthesis
Reference
1
  Authors
Rabot, S., Peerless, A.C.J. and Robins, R.J.
  Title
Tigloyl-CoA:pseudotropine acyltransferase - an enzyme of tropane alkaloid biosynthesis.
  Journal
Phytochemistry 39 (1995) 315-322.
Reference
2  [PMID:1959620]
  Authors
Robins RJ, Bachmann P, Robinson T, Rhodes MJ, Yamada Y.
  Title
The formation of 3 alpha- and 3 beta-acetoxytropanes by Datura stramonium transformed root cultures involves two acetyl-CoA-dependent acyltransferases.
  Journal
FEBS. Lett. 292 (1991) 293-7.
Reference
3
  Authors
Robins, R.J., Bachmann,P., Peerless, A.C.J. and Rabot, S.
  Title
Esterification reactions in the biosynthesis of tropane alkaloids in transformed root cultures.
  Journal
Plant Cell, Tissue Organ Cult. 38 (1994) 241-247.
Reference
4  [PMID:10626376]
  Authors
Boswell HD, Drager B, McLauchlan WR, Portsteffen A, Robins DJ, Robins RJ, Walton NJ.
  Title
Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura.
  Journal
Phytochemistry. 52 (1999) 871-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
138440-78-5 162535-26-4

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