| Entry |
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| Name |
acetyl-S-ACP:malonate ACP transferase;
acetyl-S-ACP:malonate ACP-SH transferase;
acetyl-S-acyl-carrier protein:malonate acyl-carrier-protein-transferase;
MdcA;
MadA;
ACP transferase;
malonate/acetyl-CoA transferase;
malonate:ACP transferase;
acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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| Sysname |
acetyl-[acyl-carrier-protein]:malonate S-[acyl-carrier-protein]transferase
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| Reaction(IUBMB) |
an acetyl-[acyl-carrier protein] + malonate = a malonyl-[acyl-carrier protein] + acetate [RN: R08944]
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| Reaction(KEGG) |
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| Substrate |
acetyl-[acyl-carrier protein] [CPD: C03939];
malonate [CPD: C00383]
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| Product |
malonyl-[acyl-carrier protein] [CPD: C01209];
acetate [CPD: C00033]
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| Comment |
This is the first step in the catalysis of malonate decarboxylation and involves the exchange of an acetyl thioester residue bound to the activated acyl-carrier protein (ACP) subunit of the malonate decarboxylase complex for a malonyl thioester residue [2]. This enzyme forms the alpha subunit of the multienzyme complexes biotin-independent malonate decarboxylase (EC 4.1.1.88) and biotin-dependent malonate decarboxylase (EC 4.1.1.89). The enzyme can also use acetyl-CoA as a substrate but more slowly [4].
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| Orthology |
| malonate decarboxylase alpha subunit |
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| Genes |
EFE: | | EBT: | | SES: | | ENT: | | ENC: | | ENO: | | ECLO: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | CKO: | | CRO: | | SMAF: | | DDA: | | DDC: | | DDD: | | DZE: | | PVA: | | PAO: | | RAH: | | RAQ: | | RAA: | | ROR: | | EBF: | | XCC: | | XCB: | | XCA: | | XCV: | | XCP: | | XAC: | | XAX: | | XAO: | | XCI: | | SML: | | SMT: | | BUJ: | | SMZ: | | VEJ: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PPG: | | PPW: | | PPT: | | PPUH: | | PPUU: | | PST: | | PSB: | | PSP: | | PFL: | | PFO: | | PFS: | | PFE: | | PFC: | | PPZ: | | PMK: | | PSA: | | PSZ: | | PSR: | | PSC: | | PSJ: | | PSH: | | PBA: | | PFV: | | AVN: | | AVL: | | AVD: | | PAR: | | ACI: | | ACD: | | ACB: | | ABY: | | ABC: | | ABN: | | ABB: | | ABX: | | ABZ: | | ABR: | | ABD: | | ABH: | | ABAD: | | ACC: | | PIN: | | LPN: | | LPU: | | LPP: | | LPC: | | LPA: | | LPE: | | LLO: | | PSE: | | RSC: | | RPI: | | RPF: | | REU: | | CNC: | | BMA: | | BMV: | | BML: | | BMN: | | BPS: | | BPM: | | BPL: | | BPD: | | BPR: | | BPZ: | | BPQ: | | BTE: | | BTD: | | BVI: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BAM: | | BAC: | | BMU: | | BMJ: | | BCT: | | BXE: | | BPH: | | BPY: | | BGL: | | BUG: | | BGE: | | BGF: | | BGD: | | BYI: | | BUK: | | BPX: | | AKA: | | RFR: | | PNA: | | VEI: | | DAC: | | DEL: | | VAP: | | MPT: | | HAR: | | MMS: | | HSE: | | CFU: | | LCH: | | AZA: | | DAR: | | DTI: | | BJA: | | BJU: | | BRS: | | RPB: | | RPC: | | OCA: | | OCG: | | OCO: | | SNO: | | MEX: | | MEA: | | MDI: | | MCH: | | MRD: | | MET: | | MPO: | | MNO: | | MSL: | | RCP: | | SWI: | | RRU: | | RRF: | | AZL: | | BPF: | | BMQ: | | BMD: | | BMH: | | PTA: | | SIV: | | LCR: | | EFC: | | EFU: | | EFM: | | ECAS: | | MSM: | | MSG: | | CHN: | | GMA: | |
» show all
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| Reference |
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| Authors |
Hilbi H, Dimroth P |
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| Title |
Purification and characterization of a cytoplasmic enzyme component of the Na+-activated malonate decarboxylase system of Malonomonas rubra: acetyl-S-acyl carrier protein: malonate acyl carrier protein-SH transferase. |
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| Journal |
Arch. Microbiol. 162 (1994) 48-56. |
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| Organism |
Malonomonas rubra |
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| Reference |
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| Authors |
Hoenke S, Schmid M, Dimroth P |
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| Title |
Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli. |
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| Journal |
Eur. J. Biochem. 246 (1997) 530-8. |
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| Organism |
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| Reference |
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| Authors |
Koo JH, Kim YS |
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| Title |
Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus. |
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| Journal |
Eur. J. Biochem. 266 (1999) 683-90. |
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| Organism |
Acinetobacter calcoaceticus |
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| Reference |
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| Authors |
Chohnan S, Akagi K, Takamura Y |
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| Title |
Functions of malonate decarboxylase subunits from Pseudomonas putida. |
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| Journal |
Biosci. Biotechnol. Biochem. 67 (2003) 214-7. |
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| Organism |
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| Reference |
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| Authors |
Dimroth P, Hilbi H |
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| Title |
Enzymic and genetic basis for bacterial growth on malonate. |
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| Journal |
Mol. Microbiol. 25 (1997) 3-10. |
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| Organism |
Malonomonas rubra, Klebsiella pneumoniae [GN: kpn kpe kpu] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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