KEGG   ENZYME: 2.3.1.187Help
Entry
EC 2.3.1.187                Enzyme                                 

Name
acetyl-S-ACP:malonate ACP transferase;
acetyl-S-ACP:malonate ACP-SH transferase;
acetyl-S-acyl-carrier protein:malonate acyl-carrier-protein-transferase;
MdcA;
MadA;
ACP transferase;
malonate/acetyl-CoA transferase;
malonate:ACP transferase;
acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-[acyl-carrier-protein]:malonate S-[acyl-carrier-protein]transferase
Reaction(IUBMB)
an acetyl-[acyl-carrier protein] + malonate = a malonyl-[acyl-carrier protein] + acetate [RN:R08944]
Reaction(KEGG)
Substrate
acetyl-[acyl-carrier protein] [CPD:C03939];
malonate [CPD:C00383]
Product
malonyl-[acyl-carrier protein] [CPD:C01209];
acetate [CPD:C00033]
Comment
This is the first step in the catalysis of malonate decarboxylation and involves the exchange of an acetyl thioester residue bound to the activated acyl-carrier protein (ACP) subunit of the malonate decarboxylase complex for a malonyl thioester residue [2]. This enzyme forms the alpha subunit of the multienzyme complexes biotin-independent malonate decarboxylase (EC 4.1.1.88) and biotin-dependent malonate decarboxylase (EC 4.1.1.89). The enzyme can also use acetyl-CoA as a substrate but more slowly [4].
History
EC 2.3.1.187 created 2008
Orthology
K13929  
malonate decarboxylase alpha subunit
Genes
EFE: 
SES: 
ENT: 
ENC: 
ENO: 
ECLO: 
EEC: 
ENL: 
EAS: 
EAE: 
EAR: 
ENR: 
CSI: 
CTU: 
KPN: 
KPU: 
KPM: 
KPP: 
KPE: 
KPK_2894(mdcA)
KPO: 
KPR: 
KPR_2746(mdcA)
KPJ: 
KPI: 
KVA: 
KOX: 
KOE: 
CKO: 
CRO: 
ROD_44571(mdcA)
CFD: 
SMAF: 
SERR: 
SFO: 
DDA: 
DDC: 
DDD: 
DZE: 
PVA: 
Pvag_2968(mdcA)
PAO: 
RAH: 
RAQ: 
RAA: 
EBT: 
ROR: 
EBF: 
XCC: 
XCC3609(mdcA)
XCB: 
XCA: 
XCP: 
XCV: 
XCV0594(mdcA)
XAC: 
XAC0560(mdcA)
XCI: 
XAX: 
XACM_0551(mdcA)
XAO: 
SML: 
SMT: 
BUJ: 
SMZ: 
VEJ: 
PAE: 
PA0208(mdcA)
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PDK: 
PSG: 
PRP: 
PAEP: 
PAER: 
PAEM: 
PAEL: 
PAES: 
PAEU: 
PAEG: 
PPG: 
PPW: 
PPT: 
PPUH: 
PPUT: 
PPUN: 
PP4_23620(mdcA)
PPUU: 
PST: 
PSB: 
PSYR: 
PSP: 
PCI: 
PFL: 
PFL_5820(mdcA)
PPRC: 
PFO: 
PFS: 
PFE: 
PFC: 
PPZ: 
PMK: 
PSA: 
PST_4120(mdcA)
PSZ: 
PSR: 
PSC: 
PSJ: 
PSH: 
PBA: 
PFV: 
PRE: 
PSV: 
PSK: 
PMON: 
PMOT: 
AVN: 
AVL: 
AVD: 
PAR: 
Psyc_1146(mdcA)
PSO: 
ACI: 
ACIAD1753(mdcA)
ACD: 
ACB: 
ABY: 
ABAYE2233(mdcA)
ABC: 
ABN: 
AB57_1654(mdcA)
ABB: 
ABX: 
ABZ: 
ABR: 
ABD: 
ABH: 
ABAD: 
ABJ: 
ABAB: 
ABAJ: 
ABAZ: 
ACC: 
PIN: 
LPN: 
lpg2426(mdcA)
LPU: 
LPH: 
LPV_2747(mdcA)
LPO: 
LPO_2616(mdcA)
LPM: 
LP6_2454(mdcA)
LPP: 
LPC: 
LPC_2050(mdcA)
LPA: 
LPE: 
LLO: 
LLO_2547(mdcA)
PSE: 
NH8B_2978(mdcA)
RSC: 
RPI: 
RPF: 
REU: 
CNC: 
BMA: 
BMA3037(mdcA)
BMV: 
BML: 
BMN: 
BPS: 
BPM: 
BPL: 
BPD: 
BPR: 
BPSE: 
BDL_687(mdcA)
BPSU: 
BBN_2240(mdcA)
BPZ: 
BPQ: 
BPK: 
BBK_191(mdcA)
BTE: 
BTD: 
BTI_2501(mdcA)
BVI: 
BUR: 
BCN: 
BCH: 
BCM: 
BCJ: 
BAM: 
BAC: 
BMU: 
BMJ: 
BCT: 
BXE: 
BPH: 
BPY: 
BGL: 
BUG: 
BGE: 
BGF: 
BGD: 
BYI: 
BUK: 
BPX: 
BUO: 
AKA: 
AMIM: 
RFR: 
PNA: 
VEI: 
DAC: 
DEL: 
VAP: 
MPT: 
HAR: 
HEAR1469(mdcA)
MMS: 
mma_0104(mdcA1) mma_2563(mdcA2)
HSE: 
CFU: 
CFU_1708(mdcA)
LCH: 
AZA: 
AZKH_1590(mdcA)
DAR: 
DTI: 
BJA: 
bll0270(mdcA)
BJU: 
BRS: 
S23_13470(mdcA)
RPB: 
RPC: 
OCA: 
OCAR_6872(mdcA)
OCG: 
OCO: 
SNO: 
MEX: 
MEA: 
MDI: 
METDI0024(mdcA)
MCH: 
MRD: 
MET: 
MPO: 
MNO: 
MSL: 
RCP: 
SWI: 
RRU: 
RRF: 
AZL: 
BPF: 
BMQ: 
BMQ_0796(mdcA)
BMD: 
BMD_0797(mdcA)
BMH: 
PPOL: 
PTA: 
SIV: 
SSIL_3617(mdcA)
LCR: 
EFC: 
EFAU: 
EFU: 
EFM: 
ECAS: 
MSM: 
MSG: 
CGS: 
CGG: 
CHN: 
GMA: 
 » show all
Taxonomy
Reference
1  [PMID:18251085]
  Authors
Hilbi H, Dimroth P
  Title
Purification and characterization of a cytoplasmic enzyme component of the Na+-activated malonate decarboxylase system of Malonomonas rubra: acetyl-S-acyl carrier protein: malonate acyl carrier protein-SH transferase.
  Journal
Arch. Microbiol. 162 (1994) 48-56.
  Organism
Malonomonas rubra
  Sequence
[up:O06924]
Reference
2  [PMID:9208947]
  Authors
Hoenke S, Schmid M, Dimroth P
  Title
Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli.
  Journal
Eur. J. Biochem. 246 (1997) 530-8.
  Organism
Klebsiella pneumoniae
Reference
3  [PMID:10561613]
  Authors
Koo JH, Kim YS
  Title
Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus.
  Journal
Eur. J. Biochem. 266 (1999) 683-90.
  Organism
Acinetobacter calcoaceticus
Reference
4  [PMID:12619701]
  Authors
Chohnan S, Akagi K, Takamura Y
  Title
Functions of malonate decarboxylase subunits from Pseudomonas putida.
  Journal
Biosci. Biotechnol. Biochem. 67 (2003) 214-7.
  Organism
Pseudomonas putida
Reference
5  [PMID:11902724]
  Authors
Dimroth P, Hilbi H
  Title
Enzymic and genetic basis for bacterial growth on malonate.
  Journal
Mol. Microbiol. 25 (1997) 3-10.
  Organism
Malonomonas rubra, Klebsiella pneumoniae
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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