| Entry |
|
|---|
| Name |
mycothiol synthase;
MshD
|
|---|
| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
|---|
| Sysname |
acetyl-CoA:desacetylmycothiol O-acetyltransferase
|
|---|
| Reaction(IUBMB) |
desacetylmycothiol + acetyl-CoA = CoA + mycothiol [RN: R09622]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
|
|---|
| Comment |
This enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes, including Mycobacterium [1]. The enzyme is a member of a large family of GCN5-related N-acetyltransferases (GNATs) [2]. The enzyme has been purified from Mycobacterium tuberculosis H37Rv. Acetyl-CoA is the preferred CoA thioester but propionyl-CoA is also a substrate [3].
|
|---|
| Orthology |
|
|---|
| Genes |
MSD: | | HOH: | | MTU: | | MTV: | | MTC: | | MRA: | | MTF: | | MTB: | | MTK: | | MTZ: | | MTG: | | MTI: | | MTE: | | MTL: | | MTO: | | MTD: | | MTN: | | MTJ: | | MTUB: | | MBO: | | MBB: | | MBT: | | MBM: | | MBK: | | MAF: | | MCE: | | MCQ: | | MCV: | | MCX: | | MCZ: | | MLE: | | MLB: | | MPA: | | MAV: | | MIT: | | MIR: | | MIA: | | MID: | | MSG: | | MSA: | | MUL: | | MVA: | | MGI: | | MSP: | | MAB: | | MMV: | | MMC: | | MKM: | | MJL: | | MJD: | | MMI: | | MRH: | | MMM: | | MCB: | | MLI: | | ASD: | | CGL: | | CGB: | | CGU: | | CGT: | | CEF: | | CDI: | | CDP: | | CDH: | | CDT: | | CDE: | | CDR: | | CDA: | | CDZ: | | CDB: | | CDS: | | CDD: | | CDW: | | CDV: | | CJK: | | CUR: | | CUA: | | CAR: | | CKP: | | CPU: | | CPL: | | CPG: | | CPP: | | CPK: | | CPQ: | | CPX: | | CPZ: | | COR: | | COP: | | COD: | | COS: | | COI: | | COE: | | COU: | | CRD: | | CUL: | | CUC: | | CUE: | | CVA: | | CHN: | | CCN: | | NFA: | | NCY: | | NBR: | | RHA: | | RER: | | ROP: | | REQ: | | GBR: | | GPO: | | GOR: | | TPR: | | SRT: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | STRP: | | KSK: | | CMI: | | CMS: | | CMC: | | ART: | | AAU: | | ACH: | | AAI: | | APN: | | ARR: | | RSA: | | KRH: | | MLU: | | RMU: | | RDN: | | BCV: | | BFA: | | JDE: | | KSE: | | XCE: | | IVA: | | SKE: | | CFL: | | CGA: | | ICA: | | PFR: | | PPC: | | MPH: | | NCA: | | KFL: | | TFU: | | NDA: | | NAL: | | TCU: | | SRO: | | FRA: | | FRE: | | FRI: | | FAL: | | FSY: | | ACE: | | NML: | | GOB: | | BSD: | | MMAR: | | KRA: | | SEN: | | SVI: | | TBI: | | AMD: | | AMN: | | AMM: | | PDX: | | AMI: | | SESP: | | STP: | | SAQ: | | MAU: | | MIL: | | VMA: | | AMS: | | ASE: | | CAI: | | SNA: | | AFO: | | AYM: | |
» show all
 |
|---|
| Reference |
|
|---|
| Authors |
Spies HS, Steenkamp DJ |
|---|
| Title |
Thiols of intracellular pathogens. Identification of ovothiol A in Leishmania donovani and structural analysis of a novel thiol from Mycobacterium bovis. |
|---|
| Journal |
Eur. J. Biochem. 224 (1994) 203-13. |
|---|
| Reference |
|
|---|
| Authors |
Koledin T, Newton GL, Fahey RC |
|---|
| Title |
Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes. |
|---|
| Journal |
Arch. Microbiol. 178 (2002) 331-7. |
|---|
| Reference |
|
|---|
| Authors |
Vetting MW, Roderick SL, Yu M, Blanchard JS |
|---|
| Title |
Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases. |
|---|
| Journal |
Protein. Sci. 12 (2003) 1954-9. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
|---|
