KEGG   ENZYME: 2.3.1.190Help
Entry
EC 2.3.1.190                Enzyme                                 

Name
acetoin dehydrogenase;
acetoin dehydrogenase complex;
acetoin dehydrogenase enzyme system;
AoDH ES
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:acetoin O-acetyltransferase
Reaction(IUBMB)
acetoin + CoA + NAD+ = acetaldehyde + acetyl-CoA + NADH + H+ [RN:R09524]
Reaction(KEGG)
Substrate
acetoin [CPD:C00466];
CoA [CPD:C00010];
NAD+ [CPD:C00003]
Product
acetaldehyde [CPD:C00084];
acetyl-CoA [CPD:C00024];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Requires thiamine diphosphate. This enzyme, which belongs to the family of 2-oxo acid dehydrogenase complexes, catalyses the oxidative-hydrolytic cleavage of acetoin to acetaldehyde and acetyl-CoA in many bacterial strains, both aerobic and anaerobic. The enzyme is composed of multiple copies of three enzymic components: acetoin oxidoreductase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoyl dehydrogenase (E3).
History
EC 2.3.1.190 created 2010
Reference
1  [PMID:2061286]
  Authors
Priefert H, Hein S, Kruger N, Zeh K, Schmidt B, Steinbuchel A
  Title
Identification and molecular characterization of the Alcaligenes eutrophus H16 aco operon genes involved in acetoin catabolism.
  Journal
J. Bacteriol. 173 (1991) 4056-71.
  Organism
Alcaligenes eutrophus
Reference
2  [PMID:8110297]
  Authors
Oppermann FB, Steinbuchel A
  Title
Identification and molecular characterization of the aco genes encoding the Pelobacter carbinolicus acetoin dehydrogenase enzyme system.
  Journal
J. Bacteriol. 176 (1994) 469-85.
  Organism
Pelobacter carbinolicus [GN:pca]
Reference
3  [PMID:8206840]
  Authors
Kruger N, Oppermann FB, Lorenzl H, Steinbuchel A
  Title
Biochemical and molecular characterization of the Clostridium magnum acetoin dehydrogenase enzyme system.
  Journal
J. Bacteriol. 176 (1994) 3614-30.
  Organism
Clostridium magnu
Reference
4  [PMID:7813883]
  Authors
Huang M, Oppermann FB, Steinbuchel A
  Title
Molecular characterization of the Pseudomonas putida 2,3-butanediol catabolic pathway.
  Journal
FEMS. Microbiol. Lett. 124 (1994) 141-50.
  Organism
Pseudomonas putida [GN:ppu]
Reference
5  [PMID:10368162]
  Authors
Huang M, Oppermann-Sanio FB, Steinbuchel A
  Title
Biochemical and molecular characterization of the Bacillus subtilis acetoin catabolic pathway.
  Journal
J. Bacteriol. 181 (1999) 3837-41.
  Organism
Bacillus subtilis [GN:bsu]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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