KEGG   ENZYME: 2.3.1.194Help
Entry
EC 2.3.1.194                Enzyme                                 

Name
acetoacetyl-CoA synthase;
NphT7
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:malonyl-CoA C-acetyltransferase (decarboxylating)
Reaction(IUBMB)
acetyl-CoA + malonyl-CoA = acetoacetyl-CoA + CoA + CO2 [RN:R09527]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083]
Product
acetoacetyl-CoA [CPD:C00332];
CoA [CPD:C00010];
CO2 [CPD:C00011]
Comment
The enzyme from the soil bacterium Streptomyces sp. CL190 produces acetoacetyl-CoA to be used for mevalonate production via the mevalonate pathway.
Unlike the homologous EC 2.3.1.180 (beta-ketoacyl-[acyl-carrier-protein] synthase III), this enzyme does not accept malonyl-[acyl-carrier-protein] as a substrate.
History
EC 2.3.1.194 created 2011
Orthology
K21378  
acetoacetyl-CoA synthase
Genes
MUL: 
MUL_3531(fabH_1)
MMI: 
MMAR_3221(fabH_1)
MLI: 
MULP_03448(fabH_1)
NBR: 
SVL: 
SCT: 
SCY: 
SBH: 
SDV: 
BN159_7956(fabH5)
SALS: 
SGU: 
STRM: 
SPAV: 
KSK: 
KSE_59090(fabH4)
NDA: 
FRA: 
AHM: 
ACTI: 
ACAD: 
ACTN: 
AFS: 
 » show all
Taxonomy
Reference
1  [PMID:20534558]
  Authors
Okamura E, Tomita T, Sawa R, Nishiyama M, Kuzuyama T
  Title
Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 107 (2010) 11265-70.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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