KEGG   ENZYME: 2.3.1.203Help
Entry
EC 2.3.1.203                Enzyme                                 

Name
UDP-N-acetylbacillosamine N-acetyltransferase;
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase;
pglD (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + UDP-N-acetylbacillosamine = CoA + UDP-N,N'-diacetylbacillosamine [RN:R10099]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
UDP-N-acetylbacillosamine [CPD:C04630]
Product
CoA [CPD:C00010];
UDP-N,N'-diacetylbacillosamine [CPD:C20357]
Comment
The product, UDP-N,N'-diacetylbacillosamine, is an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-asparagine residues in Campylobacter species [1,2] and O-linked glycosylation of certain L-serine residues in Neisseria species [3].
History
EC 2.3.1.203 created 2012, modified 2013
Pathway
Amino sugar and nucleotide sugar metabolism
Orthology
K15913  
UDP-N-acetylbacillosamine N-acetyltransferase
Genes
SKU: 
CJE: 
Cj1123c(pglD)
CJB: 
CJJ: 
CJU: 
C8J_1063(pglD)
CJN: 
CJI: 
CJSA_1065(pglD)
CJM: 
CJM1_1101(pglD)
CJS: 
CJP: 
CJEJ: 
CJEU: 
CJEN: 
CJEI: 
CJER: 
CJV: 
CJY: 
CJQ: 
UC78_1080(pglD)
CJL: 
CJW: 
CJR: 
CJE1265(pglD)
CJD: 
CJZ: 
CJX: 
CFF: 
CFT: 
CFV: 
CFX: 
CFZ: 
CAMP: 
CFP: 
CCV: 
CHA: 
CCO: 
CLA: 
Cla_1256(pglD)
CLR: 
CLM: 
CLQ: 
CLN: 
CLL: 
CCOL: 
CCC: 
CCQ: 
CCF: 
CCY: 
CCOI: 
CCOF: 
CCOO: 
ATE51_01358(pglD_3)
CAJ: 
CIS: 
CINS_1221(pglD)
CVO: 
CVOL_1235(pglD)
CPEL: 
CPEL_1362(pglD)
CAMR: 
CSM: 
CSF: 
CGRA: 
CURE: 
EUC: 
HYM: 
 » show all
Taxonomy
Reference
1  [PMID:17087520]
  Authors
Olivier NB, Chen MM, Behr JR, Imperiali B
  Title
In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system.
  Journal
Biochemistry. 45 (2006) 13659-69.
  Sequence
[cje:Cj1123c]
Reference
2  [PMID:18198901]
  Authors
Rangarajan ES, Ruane KM, Sulea T, Watson DC, Proteau A, Leclerc S, Cygler M, Matte A, Young NM
  Title
Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter  jejuni.
  Journal
Biochemistry. 47 (2008) 1827-36.
  Sequence
[cje:Cj1123c]
Reference
3  [PMID:21542610]
  Authors
Hartley MD, Morrison MJ, Aas FE, Borud B, Koomey M, Imperiali B
  Title
Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N'-diacetylbacillosamine.
  Journal
Biochemistry. 50 (2011) 4936-48.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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