KEGG   ENZYME: 2.3.1.208Help
Entry
EC 2.3.1.208                Enzyme                                 

Name
4-hydroxycoumarin synthase;
BIS2;
BIS3
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:2-hydroxybenzoyl-CoA malonyltransferase
Reaction(IUBMB)
malonyl-CoA + 2-hydroxybenzoyl-CoA = 2 CoA + 4-hydroxycoumarin + CO2 [RN:R10173]
Reaction(KEGG)
Substrate
malonyl-CoA [CPD:C00083];
2-hydroxybenzoyl-CoA [CPD:C20394]
Product
CoA [CPD:C00010];
4-hydroxycoumarin [CPD:C20414];
CO2 [CPD:C00011]
Comment
The enzyme, a polyketide synthase, can also accept benzoyl-CoA as substrate, which it condenses with 3 malonyl-CoA molecules to form 3,5-dihydroxybiphenyl (cf. EC 2.3.1.177, biphenyl synthase) [1].
History
EC 2.3.1.208 created 2012
Reference
1  [PMID:19757094]
  Authors
Liu B, Raeth T, Beuerle T, Beerhues L
  Title
A novel 4-hydroxycoumarin biosynthetic pathway.
  Journal
Plant. Mol. Biol. 72 (2010) 17-25.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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