KEGG   ENZYME: 2.3.1.21Help
Entry
EC 2.3.1.21                 Enzyme                                 
Name
carnitine O-palmitoyltransferase;
CPT;
CPTo;
outer malonyl-CoA inhibitable carnitine palmitoyltransferase;
CPTi;
CPT I (outer membrane carnitine palmitoyl transferase);
carnitine palmitoyltransferase I;
carnitine palmitoyltransferase II;
CPT-A;
CPT-B;
acylcarnitine transferase;
carnitine palmitoyltransferase;
carnitine palmitoyltransferase-A;
L-carnitine palmitoyltransferase;
palmitoylcarnitine transferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
palmitoyl-CoA:L-carnitine O-palmitoyltransferase
Reaction(IUBMB)
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine [RN:R01923]
Reaction(KEGG)
Substrate
palmitoyl-CoA [CPD:C00154];
L-carnitine [CPD:C00318]
Product
CoA [CPD:C00010];
L-palmitoylcarnitine [CPD:C02990]
Comment
Broad specificity to acyl group, over the range C8 to C18; optimal activity with palmitoyl-CoA. cf. EC 2.3.1.7 carnitine O-acetyltransferase and EC 2.3.1.137 carnitine O-octanoyltransferase.
Pathway
Fatty acid metabolism
Orthology
K08765  
carnitine O-palmitoyltransferase 1
K08766  
carnitine O-palmitoyltransferase 2
Genes
HSA: 
126129(CPT1C) 1374(CPT1A) 1375(CPT1B) 1376(CPT2)
PTR: 
451382(CPT1A) 470253(CPT1B) 737945(CPT2) 748258(CPT1C)
PPS: 
100969017(CPT1A) 100977928(CPT1B) 100978250(CPT1C) 100983874(CPT2)
GGO: 
101128037(CPT1A) 101141306(CPT1B) 101147238(CPT1C) 101147523(CPT2)
PON: 
100172407(CPT1C) 100442465(CPT2) 100444942(CPT1B) 100448104(CPT1A)
MCC: 
709837(CPT1A) 714150(CPT2) 720697(CPT1B)
MMU: 
12894(Cpt1a) 12895(Cpt1b) 12896(Cpt2) 78070(Cpt1c)
RNO: 
25413(Cpt2) 25756(Cpt1b) 25757(Cpt1a) 308579(Cpt1c)
CFA: 
100856778 403583(CPT1A) 481184(CPT1B) 489585(CPT2)
AML: 
FCA: 
101083187(CPT1B) 101093287(CPT2) 101095144(CPT1C) 101096105(CPT1A)
BTA: 
504502(CPT2) 506812(CPT1A) 509459(CPT1B) 513710(CPT1C)
SSC: 
100519258(CPT1C) 100519491(CPT2) 399527(CPT1A) 399528(CPT1B)
ECB: 
100009716(CPT1A) 100055438(CPT1B) 100056027(CPT1C) 100061061
MDO: 
100012188(CPT1B) 100012915 100017404(CPT2)
SHR: 
100921521 100930017(CPT1B) 100931262(CPT1A)
OAA: 
100073995 100081087 100083175 100084575 100093378
GGA: 
423118(CPT1A) 424649(CPT2)
MGP: 
100540756(CPT2) 100549362
TGU: 
100222209(CPT2) 100226785(CPT1A)
ACS: 
100554332(cpt1a) 100559925 100560465
XLA: 
379393(cpt1a) 379893(cpt2) 495682(cpt1b)
XTR: 
100135089(cpt1a) 100490391 394801(cpt2) 780223(cpt1b)
DRE: 
100005717(cpt2) 558088 560000(fc31g06)
TRU: 
101067027 101076236
OLA: 
101155805 101156059 101167863
BFO: 
BRAFLDRAFT_129894 BRAFLDRAFT_129895 BRAFLDRAFT_85684
CIN: 
100175546 100182078 100186654
SPU: 
577222 577810 577934
DME: 
Dmel_CG12891(whd) Dmel_CG2107
DPO: 
Dpse_GA11884 Dpse_GA15246
DAN: 
Dana_GF11106 Dana_GF24256
DER: 
Dere_GG14893 Dere_GG22743
DPE: 
Dper_GL17200 Dper_GL20773
DSE: 
Dsec_GM14519 Dsec_GM20519
DSI: 
Dsim_GD13716 Dsim_GD25979
DWI: 
Dwil_GK10678 Dwil_GK17625
DYA: 
Dyak_GE13102 Dyak_GE20347
DGR: 
Dgri_GH16993 Dgri_GH20631
DMO: 
Dmoj_GI11407 Dmoj_GI20192
DVI: 
Dvir_GJ13603 Dvir_GJ20140
AGA: 
AgaP_AGAP008907 AgaP_AGAP010164
AAG: 
AaeL_AAEL005458 AaeL_AAEL007536
CQU: 
CpipJ_CPIJ005612 CpipJ_CPIJ010031
AME: 
411473 550695(CPTI)
NVI: 
100121693(NV13327) 100122869(NV12317)
TCA: 
657643 660089
API: 
100159310 100164300
PHU: 
Phum_PHUM022280 Phum_PHUM616920
ISC: 
IscW_ISCW018288 IscW_ISCW023345
CEL: 
CELE_R07H5.2(cpt-2) CELE_Y46G5A.17(cpt-1)
CBR: 
CBG06027(Cbr-cpt-2) CBG07886(Cbr-cpt-1)
BMY: 
Bm1_02015 Bm1_19470
TSP: 
Tsp_06820 Tsp_10227
NVE: 
NEMVE_v1g167183 NEMVE_v1g236240 NEMVE_v1g244361
HMG: 
100206022(cpt1a) 100214547(cpt2)
TAD: 
TRIADDRAFT_50581 TRIADDRAFT_55550
AQU: 
100632782 100636209
MBR: 
MONBRDRAFT_34499
TBR: 
Tb927.7.2250(Tb07.22O10.200)
TCR: 
507211.10 511807.284
LMA: 
LMJF_22_0310
LIF: 
LINJ_19_1570 LINJ_22_0190
LDO: 
LDBPK_191570 LDBPK_220190
LMI: 
LMXM_19_1540 LMXM_22_0310
LBZ: 
LBRM_19_1800 LBRM_22_0300
PIF: 
PITG_18366 PITG_19234
MMI: 
MMAR_0691
MLI: 
MULP_00690
 » show all
Taxonomy
Reference
1
  Authors
Derrick, J.P., Tubbs, P.K. and Ramsay, R.R.
  Title
Purification and properties of an easily solubilized L-carnitine palmitoyltransferase from beef-liver mitochondria.
  Journal
Biochem. Soc. Trans. 14 (1986) 698.
Reference
2  [PMID:3342008]
  Authors
Healy MJ, Kerner J, Bieber LL.
  Title
Enzymes of carnitine acylation. Is overt carnitine palmitoyltransferase of liver peroxisomal carnitine octanoyltransferase?
  Journal
Biochem. J. 249 (1988) 231-7.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:6630173]
  Authors
Miyazawa S, Ozasa H, Osumi T, Hashimoto T.
  Title
Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver.
  Journal
J. Biochem. (Tokyo). 94 (1983) 529-42.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9068-41-1
DBGET integrated database retrieval system