Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

4-coumaroyl-CoA:malonyl-CoA 4-coumaryltransferase (bisdemethoxycurcumin-forming)

2 4-coumaroyl-CoA + malonyl-CoA + H2O = 3 CoA + bisdemethoxycurcumin + 2 CO2 [RN:R10233]

R10233

4-coumaroyl-CoA [CPD:C00223];
malonyl-CoA [CPD:C00083];
H2O [CPD:C00001]

A polyketide synthase characterized from the plant Oryza sativa (rice) that catalyses the formation of the C6-C7-C6 diarylheptanoid scaffold of bisdemethoxycurcumin. Unlike the process in the plant Curcuma longa (turmeric), where the conversion is carried out via a diketide intermediate by two different enzymes (EC 2.3.1.218, phenylpropanoylacetyl-CoA synthase and EC 2.3.1.217, curcumin synthase), the diketide intermediate formed by this enzyme remains within the enzyme's cavity and is not released to the environment.

EC 2.3.1.211 created 2013

1  [PMID:21041675]

Morita H, Wanibuchi K, Nii H, Kato R, Sugio S, Abe I

Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa.

Proc. Natl. Acad. Sci. U. S. A. 107 (2010) 19778-83.

[osa:4342896]