Entry |
|
Name |
bisdemethoxycurcumin synthase;
CUS;
curcuminoid synthase (ambiguous)
|
Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
Sysname |
4-coumaroyl-CoA:malonyl-CoA 4-coumaryltransferase (bisdemethoxycurcumin-forming)
|
Reaction(IUBMB) |
2 4-coumaroyl-CoA + malonyl-CoA + H2O = 3 CoA + bisdemethoxycurcumin + 2 CO2 [RN: R10233]
|
Reaction(KEGG) |
|
Substrate |
|
Product |
|
Comment |
A polyketide synthase characterized from the plant Oryza sativa (rice) that catalyses the formation of the C6-C7-C6 diarylheptanoid scaffold of bisdemethoxycurcumin. Unlike the process in the plant Curcuma longa (turmeric), where the conversion is carried out via a diketide intermediate by two different enzymes (EC 2.3.1.218, phenylpropanoylacetyl-CoA synthase and EC 2.3.1.217, curcumin synthase), the diketide intermediate formed by this enzyme remains within the enzyme's cavity and is not released to the environment.
|
History |
EC 2.3.1.211 created 2013
|
Pathway |
ec00945 | Stilbenoid, diarylheptanoid and gingerol biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K17212 | bisdemethoxycurcumin synthase |
|
Genes |
 |
Reference |
|
Authors |
Morita H, Wanibuchi K, Nii H, Kato R, Sugio S, Abe I |
Title |
Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa. |
Journal |
Proc. Natl. Acad. Sci. U. S. A. 107 (2010) 19778-83. |
Sequence |
|
Other DBs |
ExPASy - ENZYME nomenclature database: | 2.3.1.211 |
|