KEGG   ENZYME: 2.3.1.211Help
Entry
EC 2.3.1.211                Enzyme                                 

Name
bisdemethoxycurcumin synthase;
CUS;
curcuminoid synthase (ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
4-coumaroyl-CoA:malonyl-CoA 4-coumaryltransferase (bisdemethoxycurcumin-forming)
Reaction(IUBMB)
2 4-coumaroyl-CoA + malonyl-CoA + H2O = 3 CoA + bisdemethoxycurcumin + 2 CO2 [RN:R10233]
Reaction(KEGG)
Substrate
4-coumaroyl-CoA [CPD:C00223];
malonyl-CoA [CPD:C00083];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
bisdemethoxycurcumin [CPD:C17743];
CO2 [CPD:C00011]
Comment
A polyketide synthase characterized from the plant Oryza sativa (rice) that catalyses the formation of the C6-C7-C6 diarylheptanoid scaffold of bisdemethoxycurcumin. Unlike the process in the plant Curcuma longa (turmeric), where the conversion is carried out via a diketide intermediate by two different enzymes (EC 2.3.1.218, phenylpropanoylacetyl-CoA synthase and EC 2.3.1.217, curcumin synthase), the diketide intermediate formed by this enzyme remains within the enzyme's cavity and is not released to the environment.
History
EC 2.3.1.211 created 2013
Pathway
Stilbenoid, diarylheptanoid and gingerol biosynthesis
Biosynthesis of secondary metabolites
Orthology
K17212  
bisdemethoxycurcumin synthase
Genes
OSA: 
4342896(OJ1001_C01.122)
DOSA: 
Os07t0271500-01(Os07g0271500)
SBI: 
SORBI_02g034030(SORBIDRAFT_02g034030)
ZMA: 
100272924(GRMZM2G175812)
SITA: 
Taxonomy
Reference
1  [PMID:21041675]
  Authors
Morita H, Wanibuchi K, Nii H, Kato R, Sugio S, Abe I
  Title
Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 107 (2010) 19778-83.
  Sequence
[osa:4342896]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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