KEGG   ENZYME: 2.3.1.219Help
Entry
EC 2.3.1.219                Enzyme                                 

Name
demethoxycurcumin synthase;
CURS3
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
4-coumaroyl-CoA:feruloylacetyl-CoA feruloyltransferase (demethoxycurcumin-forming)
Reaction(IUBMB)
(1) 4-coumaroyl-CoA + feruloylacetyl-CoA + H2O = 2 CoA + demethoxycurcumin + CO2 [RN:R08809];
(2) 4-coumaroyl-CoA + (4-coumaroyl)acetyl-CoA + H2O = 2 CoA + bisdemethoxycurcumin + CO2 [RN:R08807]
Reaction(KEGG)
Substrate
4-coumaroyl-CoA [CPD:C00223];
feruloylacetyl-CoA [CPD:C17741];
H2O [CPD:C00001];
(4-coumaroyl)acetyl-CoA [CPD:C17740]
Product
CoA [CPD:C00010];
demethoxycurcumin [CPD:C17742];
CO2 [CPD:C00011];
bisdemethoxycurcumin [CPD:C17743]
Comment
A polyketide synthase from the plant Curcuma longa (turmeric). Three isoforms exist, CURS1, CURS2 and CURS3. While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate (cf. EC 2.3.1.217, curcumin synthase), CURS3 can accept 4-coumaroyl-CoA equally well [1].
History
EC 2.3.1.219 created 2013
Pathway
Stilbenoid, diarylheptanoid and gingerol biosynthesis
Biosynthesis of secondary metabolites
Orthology
K17211  
curcumin/demethoxycurcumin synthase
Reference
1  [PMID:19622354]
  Authors
Katsuyama Y, Kita T, Horinouchi S
  Title
Identification and characterization of multiple curcumin synthases from the herb  Curcuma longa.
  Journal
FEBS. Lett. 583 (2009) 2799-803.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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