KEGG   ENZYME: 2.3.1.22Help
Entry
EC 2.3.1.22                 Enzyme                                 

Name
2-acylglycerol O-acyltransferase;
acylglycerol palmitoyltransferase;
monoglyceride acyltransferase;
acyl coenzyme A-monoglyceride acyltransferase;
monoacylglycerol acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:2-acylglycerol O-acyltransferase
Reaction(IUBMB)
acyl-CoA + 2-acylglycerol = CoA + diacylglycerol [RN:R01368]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
2-acylglycerol [CPD:C02112]
Product
CoA [CPD:C00010];
diacylglycerol [CPD:C00165]
Comment
Various 2-acylglycerols can act as acceptor; palmitoyl-CoA and other long-chain acyl-CoAs can act as donors. The sn-1 position and the sn-3 position are both acylated, at about the same rate.
History
EC 2.3.1.22 created 1972, modified 1986, modified 1989
Pathway
Glycerolipid metabolism
Orthology
K14456  
2-acylglycerol O-acyltransferase 3
K14457  
2-acylglycerol O-acyltransferase 2
K14458  
2-acylglycerol O-acyltransferase 1
Genes
HSA: 
116255(MOGAT1) 346606(MOGAT3) 80168(MOGAT2)
PTR: 
466713(MOGAT2) 470662(MOGAT1) 472468(MOGAT3)
PPS: 
100969446(MOGAT3) 100977021(MOGAT1) 100987539(MOGAT2)
GGO: 
101150469(MOGAT3) 101154398(MOGAT1)
PON: 
100433710(MOGAT1) 100439588(MOGAT3) 100441845(MOGAT2)
MCC: 
696347(MOGAT2) 705924(MOGAT1) 714110
MCF: 
102116598(MOGAT3) 102126160(MOGAT2) 102137110(MOGAT1)
MMU: 
233549(Mogat2) 68393(Mogat1)
RNO: 
363261(Mogat1) 681211(Mogat2)
CGE: 
100761111(Mogat1) 100766858(Mogat2) 100769277(Mogat3)
HGL: 
101699301(Mogat2)
TUP: 
102471587(MOGAT3) 102491887(MOGAT1) 102493711(MOGAT2)
CFA: 
485186(MOGAT2) 488548(MOGAT1) 608245(MOGAT3)
AML: 
FCA: 
101083285(MOGAT1) 101089413(MOGAT3) 101091142(MOGAT2)
PTG: 
102952433(MOGAT2) 102961119(MOGAT1) 102971732(MOGAT3)
BTA: 
407225(MOGAT1) 538034 614494(MOGAT2) 618076(MOGAT3)
BOM: 
PHD: 
CHX: 
102170308(MOGAT3) 102172465 102173866(MOGAT2) 102185127(MOGAT1)
SSC: 
100312975(MOGAT2) 100524113(MOGAT1) 100624333(MOGAT3)
CFR: 
102503858(MOGAT2) 102507541(MOGAT1) 102519554(MOGAT3)
BACU: 
103016634(MOGAT1) 103017989(MOGAT2) 103018879(MOGAT3)
ECB: 
100056612(MOGAT1) 100060232(MOGAT3) 100064445(MOGAT2)
MYB: 
102249575(MOGAT3) 102259678(MOGAT1) 102262485(MOGAT2)
MYD: 
102753751(MOGAT2) 102755787(MOGAT3) 102772777(MOGAT1)
PALE: 
102880645(MOGAT1) 102881221(MOGAT3) 102884303(MOGAT2)
MDO: 
100011167(MOGAT2) 100015756(MOGAT1) 100017805(MOGAT3)
SHR: 
100920462(MOGAT1) 100922391(MOGAT3) 100927776
OAA: 
100087222(MOGAT2) 100089507(MOGAT3)
GGA: 
100859237 424811(MOGAT1) 426437(MOGAT2)
MGP: 
TGU: 
100220494(MOGAT1) 100229675(MOGAT2)
FAB: 
101810912(MOGAT2) 101815861(MOGAT1)
PHI: 
102103506(MOGAT1) 102107960(MOGAT2)
APLA: 
101796902(MOGAT1) 101799311(MOGAT2)
FPG: 
101921029(MOGAT2) 101922229(MOGAT1)
FCH: 
102051941(MOGAT2) 102055779(MOGAT1)
CLV: 
102090921(MOGAT1) 102091066(MOGAT2)
ASN: 
102371385 102381661(MOGAT3) 102382527(MOGAT1)
AMJ: 
102562878(MOGAT3)
PSS: 
102443911(MOGAT3) 102449089(MOGAT1) 102453102
CMY: 
ACS: 
XLA: 
380391(dgat2l1-a) 496214(mogat2.1) 735031(mogat1)
XTR: 
100145079(mogat1) 496754(mogat2.1) 734060(mogat1)
DRE: 
100142647(mogat3a) 450063(mogat2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
409905(GB13930)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
CEL: 
CELE_K07B1.4(K07B1.4) CELE_W01A11.2(dgtr-1)
CBR: 
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0011s14890g(POPTRDRAFT_232754)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0714100-01(Os02g0714100) Os06t0326700-01(Os06g0326700)
OBR: 
BDI: 
SBI: 
SORBI_04g030010(SORBIDRAFT_04g030010)
ZMA: 
SITA: 
ATR: 
s00022p00123300(AMTR_s00022p00123300) s00111p00149430(AMTR_s00111p00149430)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
MIS: 
MPP: 
CSL: 
CVR: 
SCE: 
YOR245C(DGA1)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B01630(NCAS0B01630)
NDI: 
NDAI_0E01160(NDAI0E01160)
TPF: 
TPHA_0D01250(TPHA0D01250)
TBL: 
TBLA_0C01870(TBLA0C01870)
DHA: 
PIC: 
LEL: 
CLU: 
NCR: 
PAN: 
MGR: 
FGR: 
BFU: 
AFM: 
AOR: 
AOR_1_1514014(AO090026000845)
ANG: 
ANI_1_6114(An13g00040)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
URE: 
PNO: 
TML: 
SPO: 
CNE: 
CNB: 
LBC: 
CCI: 
SCM: 
UMA: 
MGL: 
MBR: 
DDI: 
DPP: 
TGO: 
PTM: 
PTI: 
PIF: 
EHX: 
GTT: 
TBR: 
Tb927.3.1700(Tb03.30P12.310)
TCR: 
LMA: 
LIF: 
 » show all
Taxonomy
Reference
1  [PMID:4016575]
  Authors
Manganaro F, Kuksis A.
  Title
Purification and preliminary characterization of 2-monoacylglycerol acyltransferase from rat intestinal villus cells.
  Journal
Can. J. Biochem. Cell. Biol. 63 (1985) 341-7.
  Organism
Rattus norvegicus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9055-17-8

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