KEGG   ENZYME: 2.3.1.220Help
Entry
EC 2.3.1.220                Enzyme                                 

Name
2,4,6-trihydroxybenzophenone synthase;
benzophenone synthase (ambiguous);
BPS (ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:benzoyl-CoA malonyltransferase (2,4,6-trihydroxybenzophenone-forming)
Reaction(IUBMB)
3 malonyl-CoA + benzoyl-CoA = 4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO2 [RN:R02447]
Reaction(KEGG)
Substrate
malonyl-CoA [CPD:C00083];
benzoyl-CoA [CPD:C00512]
Product
CoA [CPD:C00010];
2,4,6-trihydroxybenzophenone [CPD:C06356];
CO2 [CPD:C00011]
Comment
Involved in the biosynthesis of plant xanthones. The enzyme from the plant Hypericum androsaemum L can use 3-hydroxybenzoyl-CoA instead of benzoyl-CoA, but with lower activity (cf. EC 2.3.1.151, 2,3',4,6-tetrahydroxybenzophenone synthase).
History
EC 2.3.1.220 created 2013
Reference
1  [PMID:9459298]
  Authors
Schmidt W, Beerhues L
  Title
Alternative pathways of xanthone biosynthesis in cell cultures of Hypericum androsaemum L.
  Journal
FEBS. Lett. 420 (1997) 143-6.
  Sequence
Reference
2  [PMID:22390826]
  Authors
Nualkaew N, Morita H, Shimokawa Y, Kinjo K, Kushiro T, De-Eknamkul W, Ebizuka Y, Abe I
  Title
Benzophenone synthase from Garcinia mangostana L. pericarps.
  Journal
Phytochemistry. 77 (2012) 60-9.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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