KEGG   ENZYME: 2.3.1.221Help
Entry
EC 2.3.1.221                Enzyme                                 

Name
noranthrone synthase;
polyketide synthase A (ambiguous);
PksA (ambiguous);
norsolorinic acid anthrone synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:hexanoate malonyltransferase (norsolorinic acid anthrone-forming)
Reaction(IUBMB)
7 malonyl-CoA + hexanoyl-[acyl-carrier protein] = 7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O [RN:R10239]
Reaction(KEGG)
Substrate
malonyl-CoA [CPD:C00083];
hexanoyl-[acyl-carrier protein] [CPD:C05749]
Product
CoA [CPD:C00010];
norsolorinic acid anthrone [CPD:C20453];
[acyl-carrier protein] [CPD:C00229];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A multi-domain polyketide synthase involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus. The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by a dedicated fungal fatty acid synthase [1].
History
EC 2.3.1.221 created 2013
Pathway
Aflatoxin biosynthesis
Orthology
K15316  
noranthrone synthase
Genes
PAN: 
ANI: 
AOR: 
AOR_1_20014(AO090026000009)
AFV: 
CIM: 
CPW: 
Taxonomy
Reference
1  [PMID:18403714]
  Authors
Crawford JM, Thomas PM, Scheerer JR, Vagstad AL, Kelleher NL, Townsend CA
  Title
Deconstruction of iterative multidomain polyketide synthase function.
  Journal
Science. 320 (2008) 243-6.
Reference
2  [PMID:19847268]
  Authors
Crawford JM, Korman TP, Labonte JW, Vagstad AL, Hill EA, Kamari-Bidkorpeh O, Tsai SC, Townsend CA
  Title
Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization.
  Journal
Nature. 461 (2009) 1139-43.
Reference
3  [PMID:20332208]
  Authors
Korman TP, Crawford JM, Labonte JW, Newman AG, Wong J, Townsend CA, Tsai SC
  Title
Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 107 (2010) 6246-51.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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