KEGG   ENZYME: 2.3.1.228Help
Entry
EC 2.3.1.228                Enzyme                                 

Name
isovaleryl-homoserine lactone synthase;
IV-HSL synthase;
BjaI
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
isovaleryl-CoA:S-adenosyl-L-methionine isovaleryltranserase (lactone-forming, methylthioadenosine-releasing)
Reaction(IUBMB)
isovaleryl-CoA + S-adenosyl-L-methionine = CoA + S-methyl-5'-thioadenosine + N-isovaleryl-L-homoserine lactone [RN:R10526]
Reaction(KEGG)
Substrate
isovaleryl-CoA [CPD:C02939];
S-adenosyl-L-methionine [CPD:C00019]
Product
CoA [CPD:C00010];
S-methyl-5'-thioadenosine [CPD:C00170];
N-isovaleryl-L-homoserine lactone [CPD:C20673]
Comment
The enzyme, found in the bacterium Bradyrhizobium japonicum, does not accept isovaleryl-[acyl-carrier protein] as acyl donor (cf. EC 2.3.1.184, acyl-homoserine-lactone synthase).
History
EC 2.3.1.228 created 2013
Orthology
K18096  acyl-homoserine lactone synthase
Genes
MLO: mlr5638 mlr9546
MLN: A9174_33415
MCI: Mesci_2559 Mesci_5994
MOP: Mesop_2739 Mesop_2831 Mesop_6641
MAM: Mesau_02680 Mesau_06035
MAMO: A6B35_07925
MESO: BSQ44_20295
MESW: A9K65_013700 A9K65_032155
MES: Meso_2312
HOE: IMCC20628_01503
AVI: Avi_9666
RLE: pRL100164(rhiI)
BJA: blr1063
BRA: BRADO0941
BBT: BBta_7113
BRS: S23_67510
RPA: RPA0320
RPC: RPC_0701
RPE: RPE_2323
NWI: Nwi_0626
OCA: OCAR_7682
VGO: GJW-30_1_04004(bjaI)
MEX: Mext_4513
MEA: Mex_1p4961(mlaI) Mex_2p0693(msaI)
MDI: METDI5550
MCH: Mchl_4976
MET: M446_5461
MPO: Mpop_5028
MNO: Mnod_1765
MOR: MOC_6267(solI)
META: Y590_23010
MAQU: Maq22A_1p31045(lasI) Maq22A_c03535(lasI)
BVR: BVIR_1467
MCG: GL4_0847
PZU: PHZ_p0006
HBA: Hbal_1825
SPHP: LH20_04990
SMAZ: LH19_03710
SPHM: G432_20230
SSAN: NX02_19575
SPHD: HY78_28410
SSY: SLG_19630
SPMI: K663_12625
SINB: SIDU_12120
BLAS: BSY18_4072
TMO: TMO_c0698(rhlI)
 » show all
Taxonomy
Reference
1  [PMID:21949379]
  Authors
Lindemann A, Pessi G, Schaefer AL, Mattmann ME, Christensen QH, Kessler A, Hennecke H, Blackwell HE, Greenberg EP, Harwood CS
  Title
Isovaleryl-homoserine lactone, an unusual branched-chain quorum-sensing signal from the soybean symbiont Bradyrhizobium japonicum.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 108 (2011) 16765-70.
  Sequence
[bja:blr1063]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.228
IUBMB Enzyme Nomenclature: 2.3.1.228
ExPASy - ENZYME nomenclature database: 2.3.1.228
BRENDA, the Enzyme Database: 2.3.1.228

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