| Entry |
|
|---|
| Name |
1-acylglycerophosphocholine O-acyltransferase;
lysolecithin acyltransferase;
1-acyl-sn-glycero-3-phosphocholine acyltransferase;
acyl coenzyme A-monoacylphosphatidylcholine acyltransferase;
acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase;
lysophosphatide acyltransferase;
lysophosphatidylcholine acyltransferase |
|---|
| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
|---|
| Sysname |
acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase |
|---|
| Reaction(IUBMB) |
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA +
1,2-diacyl-sn-glycero-3-phosphocholine [RN:R01318] |
|---|
| Reaction(KEGG) |
R01318;
(other) R04480
 |
|---|
| Substrate |
acyl-CoA [CPD:C00040];
1-acyl-sn-glycero-3-phosphocholine [CPD:C04230] |
|---|
| Product |
CoA [CPD:C00010];
1,2-diacyl-sn-glycero-3-phosphocholine [CPD:C00157] |
|---|
| Comment |
Acts preferentially with unsaturated acyl-CoA derivatives.
1-Acyl-sn-glycero-3-phosphoinositol can also act as acceptor. |
|---|
| Pathway |
ec00564 Glycerophospholipid metabolism |
|---|
| Orthology |
K13510 lysophosphatidylcholine acyltransferase / lyso-PAF
acetyltransferase
K13512 lysophospholipid acyltransferase
K13515 lysophospholipid acyltransferase 5
K13519 lysophospholipid acyltransferase |
|---|
| Genes |
HSA: 10162(LPCAT3) 254531(LPCAT4) 54947(LPCAT2) 79888(LPCAT1)
PTR: 451807(LPCAT3) 453302(LPCAT4) 454095(LPCAT2) 461698(LPCAT1)
MCC: 696388(LPCAT4) 698605(LPCAT2) 710144(LPCAT1) 714639(LPCAT3)
MMU: 14792(Lpcat3) 210992(Lpcat1) 270084(Lpcat2) 99010(Lpcat4)
RNO: 296048(Lpcat4) 307713(Lpcat2) 361467(Lpcat1) 362434(Lpcat3)
CFA: 478238(LPCAT4) 486715(LPCAT3) 488066(LPCAT1) 611330(LPCAT2)
BTA: 510842(LPCAT4) 514646(LPCAT2) 515361(LPCAT3) 788450(LPCAT1)
SSC: 100152542(LPCAT4) 100157372
ECB: 100053035(LPCAT3) 100061308(LPCAT2) 100071891 100071898
MDO: 100014768 100015539 100016730 100031531
OAA: 100074850 100077162 100084970
GGA: 415716(AYTL1) 418293(MBOAT5) 420974(AYTL2)
TGU: 100224379 100225934 100231699
XLA: 446240(lpcat4) 447297(lpcat3)
XTR: 100124943(lpcat2) 548367(lpcat4)
DRE: 327566(fi17g10) 553683(MGC112165) 555566 555969(lpcat1)
BFO: BRAFLDRAFT_222039 BRAFLDRAFT_80751
CIN: 100181981 100186495
SPU: 579107 580778
DME: Dmel_CG32699 Dmel_CG9655(nes)
DPO: Dpse_GA21944 Dpse_GA23062 Dpse_GA25467
DAN: Dana_GF10775 Dana_GF22630
DER: Dere_GG13418 Dere_GG18969
DPE: Dper_GL13112 Dper_GL20914 Dper_GL25842
DSE: Dsec_GM11357 Dsec_GM14886
DSI: Dsim_GD12294 Dsim_GD16057
DWI: Dwil_GK10139 Dwil_GK19695
DYA: Dyak_GE15443 Dyak_GE22515 Dyak_GE22919
DGR: Dgri_GH12406 Dgri_GH14422
DMO: Dmoj_GI13549 Dmoj_GI15857
DVI: Dvir_GJ11908 Dvir_GJ19019
AGA: AgaP_AGAP000596 AgaP_AGAP012258
AAG: AaeL_AAEL001448 AaeL_AAEL005583
CQU: CpipJ_CPIJ005745
AME: 550970(GB11725) 724443(nes)
NVI: 100120270(NV17021) 100121021(nes)
TCA: 657636 661890
API: 100169605(ACYPI010208)
PHU: Phum_PHUM293230 Phum_PHUM575140
ISC: IscW_ISCW005220
CEL: R155.1
CBR: CBG11740
BMY: Bm1_43565
SMM: Smp_132850.1 Smp_169040
HMG: 100203846
TAD: TRIADDRAFT_57453 TRIADDRAFT_63570
ATH: AT1G80950 AT2G45670
POP: POPTR_1098087 POPTR_591825 POPTR_851914
RCU: RCOM_1593790 RCOM_1612980
VVI: 100262557 100267860
OSA: 4338527(Os05g0357800) 4342043(Os06g0712300)
SBI: SORBI_03g012600 SORBI_10g029780
ZMA: 100191712 100193648(cl15598_1c) 100284702
PPP: PHYPADRAFT_163873 PHYPADRAFT_201778 PHYPADRAFT_213782
PHYPADRAFT_43926
CRE: CHLREDRAFT_189038
CME: CMS008C
SCE: YOR175C(ALE1)
AGO: AGOS_AGR271C
KLA: KLLA0F20163g
LTH: KLTH0G15422g
PIC: PICST_61839
PPA: PAS_chr3_0271
PGU: PGUG_00429
VPO: Kpol_1042p12
LEL: LELG_02472
ZRO: ZYRO0D14212g
CAL: CaO19.1881
CTP: CTRG_01687
CDU: CD36_21750
CGR: CAGL0L04642g
YLI: YALI0F19514g
CLU: CLUG_04619
SPO: SPBC16A3.10
NCR: NCU06194
PAN: PODANSg4820
MGR: MGG_08856(MG08856.4)
ANI: AN6530.2
AFM: AFUA_6G04860
AOR: AO090701000052
ANG: An15g00450
AFV: AFLA_055110
ACT: ACLA_095670
PCS: Pc12g04190
NFI: NFIA_051420
CIM: CIMG_02658
URE: UREG_03097
SSL: SS1G_00426
BFU: BC1G_00685
PNO: SNOG_15376
CNE: CNA03380
CNB: CNBA3250
LBC: LACBIDRAFT_303772
MPR: MPER_02808
UMA: UM01407.1
MGL: MGL_1418
MBR: MONBRDRAFT_33064
NGR: NAEGRDRAFT_33112
PTM: GSPATT00003417001
GLA: GL50803_15987
 |
|---|
Reference
Authors
Title
Journal
|
1 [PMID:6250446]
Bell RM, Coleman RA.
Enzymes of glycerolipid synthesis in eukaryotes.
Annu. Rev. Biochem. 49 (1980) 459-87. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:5661029]
Hill EE, Lands WE.
Incorporation of long-chain and polyunsaturated acids into
phosphatidate and phosphatidylcholine.
Biochim. Biophys. Acta. 152 (1968) 645-8.
Rattus norvegicus [GN:rno], Cavia porcellus |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:598375]
Miki Y, Hosaka K, Yamashita S, Handa H, Numa S.
Acyl-acceptor specificities of 1-acylglycerolphosphate
acyltransferase and 1-acylglycerophosphorylcholine acyltransferase
resolved from rat liver microsomes.
Eur. J. Biochem. 81 (1977) 433-41.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:6078124]
van den Bosch H, van Golde LM, Eibl H, van Deenen LL.
The acylation of 1-acylglycero-3-phosphorylcholines by rat-liver
microsomes.
Biochim. Biophys. Acta. 144 (1967) 613-23.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.3.1.23
IUBMB Enzyme Nomenclature: 2.3.1.23
ExPASy - ENZYME nomenclature database: 2.3.1.23
BRENDA, the Enzyme Database: 2.3.1.23
CAS: 9027-64-9 |
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