KEGG   ENZYME: 2.3.1.233Help
Entry
EC 2.3.1.233                Enzyme                                 

Name
1,3,6,8-tetrahydroxynaphthalene synthase;
PKS1;
THNS;
SCO1206;
RppA
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA C-acyl transferase (1,3,6,8-tetrahydroxynaphthalene forming)
Reaction(IUBMB)
5 malonyl-CoA = 1,3,6,8-tetrahydroxynaphthalene + 5 CoA + 5 CO2 + H2O [RN:R10965]
Reaction(KEGG)
Substrate
malonyl-CoA [CPD:C00083]
Product
1,3,6,8-tetrahydroxynaphthalene [CPD:C04033];
CoA [CPD:C00010];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
Isolated from the fungus Colletotrichum lagenarium [1], and the bacteria Streptomyces coelicolor [2,3] and Streptomyces peucetius [4]. It only uses malonyl-CoA, without invovement of acetyl-CoA.
History
EC 2.3.1.233 created 2014
Orthology
K19580  
1,3,6,8-tetrahydroxynaphthalene synthase
Genes
SGL: 
SOD: 
PCI: 
RSM: 
SCL: 
sce2133(rppA)
SCO: 
SCO1206(2SCG58.06)
SMA: 
SAV_7131(rppA)
SGR: 
SGR_6620(rppA)
SGB: 
SCT: 
SCAT_5029(rppA)
SCY: 
SHY: 
SHO: 
SVE: 
SDV: 
SALB: 
SFI: 
SCI: 
SALU: 
SALL: 
SLV: 
STRE: 
SLD: 
SXI: 
STRC: 
SCZ: 
SRW: 
SLE: 
sle_24280(sle_24280)
FRI: 
FSY: 
SEN: 
SACE_1243(rppA)
KPHY: 
 » show all
Taxonomy
Reference
1  [PMID:10913297]
  Authors
Fujii I, Mori Y, Watanabe A, Kubo Y, Tsuji G, Ebizuka Y
  Title
Enzymatic synthesis of 1,3,6,8-tetrahydroxynaphthalene solely from malonyl coenzyme A by a fungal iterative type I polyketide synthase PKS1.
  Journal
Biochemistry. 39 (2000) 8853-8.
Reference
2  [PMID:12905073]
  Authors
Izumikawa M, Shipley PR, Hopke JN, O'Hare T, Xiang L, Noel JP, Moore BS
  Title
Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2).
  Journal
J. Ind. Microbiol. Biotechnol. 30 (2003) 510-5.
  Sequence
[sco:SCO1206]
Reference
3  [PMID:15265863]
  Authors
Austin MB, Izumikawa M, Bowman ME, Udwary DW, Ferrer JL, Moore BS, Noel JP
  Title
Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates.
  Journal
J. Biol. Chem. 279 (2004) 45162-74.
Reference
4  [PMID:18612244]
  Authors
Ghimire GP, Oh TJ, Liou K, Sohng JK
  Title
Identification of a cryptic type III polyketide synthase (1,3,6,8-tetrahydroxynaphthalene synthase) from Streptomyces peucetius ATCC 27952.
  Journal
Mol. Cells. 26 (2008) 362-7.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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