KEGG   ENZYME: 2.3.1.235Help
Entry
EC 2.3.1.235                Enzyme                                 

Name
tetracenomycin F2 synthase;
TCM PKS
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:acetate malonyltransferase (tetracenomycin F2 forming)
Reaction(IUBMB)
10 malonyl-CoA = tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O [RN:R10960]
Reaction(KEGG)
R10960;
(other) R06643 R09269
Show
Substrate
malonyl-CoA [CPD:C00083]
Product
tetracenomycin F2 [CPD:C12366];
CoA [CPD:C00010];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A multi-domain polyketide synthase involved in the synthesis of tetracenomycin in the bacterium Streptomyces glaucescens. It involves a ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN). A malonyl-CoA molecule is initially bound to the acyl carrier protein and decarboxylated to form an acetyl starter unit. Additional two-carbon units are added from nine more malonyl-CoA molecules.
History
EC 2.3.1.235 created 2014
Pathway
Biosynthesis of type II polyketide backbone
Biosynthesis of antibiotics
Orthology
K05551  
minimal PKS ketosynthase (KS/KS alpha)
K15886  
multifunctional cyclase / dehydratase / O-methyltransferase
Genes
NBR: 
NNO: 
SCO: 
SCO5087(actIORF1)
SMA: 
SAV_2376(pks9-4)
SSX: 
SFA: 
SBH: 
SHY: 
SHO: 
SVE: 
SDV: 
SALS: 
STRP: 
F750_1305(whiE-KS)
SFI: 
SCI: 
SALU: 
SALL: 
SLV: 
SGU: 
SVT: 
STRE: 
SCW: 
SLD: 
SXI: 
STRC: 
SAMB: 
SPRI: 
SCZ: 
SCX: 
SRW: 
STRF: 
LMOI: 
TFU: 
TCU: 
SRO: 
FRA: 
FRI: 
SVI: 
AMD: 
AMED_5435(fabF)
AMN: 
AMM: 
AMES_5370(fabF)
AMZ: 
B737_5370(fabF)
ALU: 
PSEQ: 
PECQ: 
PHH: 
SESP: 
KAL: 
KPHY: 
LED: 
AHM: 
ALL: 
STP: 
MAU: 
MIL: 
VMA: 
AMS: 
ACTN: 
CAI: 
 » show all
Taxonomy
Reference
1  [PMID:9609708]
  Authors
Bao W, Wendt-Pienkowski E, Hutchinson CR
  Title
Reconstitution of the iterative type II polyketide synthase for tetracenomycin F2 biosynthesis.
  Journal
Biochemistry. 37 (1998) 8132-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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