KEGG   ENZYME: 2.3.1.237Help
Entry
EC 2.3.1.237                Enzyme                                 

Name
neocarzinostatin naphthoate synthase;
naphthoic acid synthase;
NNS;
ncsB (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:acetyl-CoA malonyltransferase (2-hydroxy-5-methyl-1-naphthoic acid forming)
Reaction(IUBMB)
acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+ = 2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+ [RN:R11125]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
2-hydroxy-5-methyl-1-naphthoate [CPD:C20856];
CoA [CPD:C00010];
CO2 [CPD:C00011];
H2O [CPD:C00001];
NADP+ [CPD:C00006]
Comment
A multi-domain polyketide synthase involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus.
History
EC 2.3.1.237 created 2014
Pathway
ec01059  Biosynthesis of enediyne antibiotics
ec01130  Biosynthesis of antibiotics
Orthology
K20422  neocarzinostatin naphthoate synthase
Genes
SEN: SACE_5532
SAQ: Sare_4951
ACTN: L083_3191(pks3C)
Taxonomy
Reference
1  [PMID:15147895]
  Authors
Sthapit B, Oh TJ, Lamichhane R, Liou K, Lee HC, Kim CG, Sohng JK
  Title
Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus.
  Journal
FEBS. Lett. 566 (2004) 201-6.
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.237
IUBMB Enzyme Nomenclature: 2.3.1.237
ExPASy - ENZYME nomenclature database: 2.3.1.237
BRENDA, the Enzyme Database: 2.3.1.237

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